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Clinical trials for Cancer in United States

7258 results

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A Phase I/IIa Study of AZD8205 Given Alone or in Combination With Anticancer Drugs, in Participants With Advanced or Metastatic Solid Malignancies

Study ID: NCT05123482
Start Date: 2021-10-18
End Date: 2027-03-26
Study Type

Interventional

Study Phase

Phase2

No. of Participants

370

Intervention / Treatment

Azd8205

AZD8205 and AZD2936 (Rilvegostomig)

AZD8205 and AZD5305 (saruparib)

AZD8205 and AZD5305 (saruparib) and AZD2936 (rilvegostomig)

Sponsor

AstraZeneca

Source: clinicaltrials.gov

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Breast Margin Study: Routine Cavity Shave Margins Vs. Selective Margins Using Savi Scout®

Study ID: NCT05825482
Start Date: 2023-07-17
End Date: 2026-11
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

204

Intervention / Treatment

Arm 1 Partial mastectomy with Savi Scout® localization and shave margins.

Arm 2 Partial mastectomy with Savi Scout® localization and selective shave margins.

Sponsor

Case Comprehensive Cancer Center

Source: clinicaltrials.gov

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A Study of Sacituzumab Govitecan Given at an Alternative Dose and Schedule in Participants With Advanced Triple-Negative Breast Cancer

Study ID: NCT06926920
Start Date: 2025-04-30
End Date: 2028-06
Study Type

Interventional

Study Phase

Phase2

No. of Participants

100

Intervention / Treatment

SATITUSUMAB Govitan-Kziy (SG)

Sponsor

Gilead Sciences

Source: clinicaltrials.gov

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Effect of Moderate Renal Impairment and Race/Ethnicity on Treosulfan Pharmacokinetics

Study ID: NCT05534620
Start Date: 2024-02-01
End Date: 2025-12
Study Type

Interventional

Study Phase

Phase1

No. of Participants

36

Intervention / Treatment

Treosulfan

Fludarabine

Sponsor

MEDA GMH

Source: clinicaltrials.gov

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Study Evaluating Tarlatamab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (LS-SCLC)

Study ID: NCT06117774
Start Date: 2024-02-20
End Date: 2029-10-31
Study Type

Interventional

Study Phase

Phase3

No. of Participants

400

Intervention / Treatment

Liquid

Placebo

Sponsor

Amgen

Source: clinicaltrials.gov

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A Dose Escalation Study of HBI-2438 in Patients With Solid Tumors Harboring KRAS G12C Mutation

Study ID: NCT05485974
Start Date: 2022-08-01
End Date: 2025-08
Study Type

Interventional

Study Phase

Phase1

No. of Participants

44

Intervention / Treatment

HBI-2438

Sponsor

HUYABIO International, LLC.

Source: clinicaltrials.gov

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Decision Making Tool in Supporting Decision Making in Contralateral Prophylactic Mastectomy in Patients With Newly Diagnosed Breast Cancer

Study ID: NCT02918474
Start Date: 2017-04-28
End Date: 2026-09-30
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

15

Intervention / Treatment

Decision Aid

Administration questionnaire

Sponsor

M.D. Anderson Cancer Center

Source: clinicaltrials.gov

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Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors

Study ID: NCT05887882
Start Date: 2024-05-31
End Date: 2027-12-31
Study Type

Interventional

Study Phase

Phase1

No. of Participants

24

Intervention / Treatment

Universal Donor (UD) Transforming growth factor beta imprinting (TGFβi) Natural Killer (NK) Cells

Implantation

Magnetic Resonance Imaging (MRI)

Quality-of-Life Assessment

Sponsor

Sabine Mueller, MD, PhD

Source: clinicaltrials.gov

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Use of Serial Plasma NGS as a New Efficacy Metric to Guide Immunotherapy Treatment Discontinuation

Study ID: NCT06146920
Start Date: 2024-01-10
End Date: 2028-11
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

39

Intervention / Treatment

Evaluation of ctDNA using the F1T after 1 year of immunotherapy

Sponsor

Massachusetts General Hospital

Source: clinicaltrials.gov

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CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies

Study ID: NCT04186520
Start Date: 2020-05-18
End Date: 2028-06-01
Study Type

Interventional

Study Phase

Phase2

No. of Participants

100

Intervention / Treatment

8/12-Day Production of Car-T Cells

8/12-Day Production of Cryopreserved Car-T Cells

12-Day Production of Car-T Cells

Sponsor

Medical College of Wisconsin

Source: clinicaltrials.gov

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