Children's Oncology Group
This study assesses how blood cell growth patterns (clonal hematopoiesis), relates to heart health or cardiovascular disease (CVD) after treatment in patients with Hodgkin lymphoma. In some patients, cancer treatment at a young age may lead to later complications, including problems with heart health. Checking for blood cell growth patterns called therapy-related clonal hematopoiesis (t-CH) can help predict who might be at risk for heart health problems after Hodgkin lymphoma treatment. If doctors know who may be at greater risk for developing later heart complications, then they can more closely monitor those patients to prevent or detect heart complications early.
Cardiovascular Disorder
Clonal Hematopoiesis
Hodgkin Lymphoma
Biospecimen Collection
Electronic Health Record Review
Magnetic Resonance Imaging
Survey Administration
PRIMARY OBJECTIVES: I. To assess the prevalence of participants in AHOD1331 with therapy-related clonal hematopoiesis (t-CH) possessing somatic mutations associated with cardiovascular disease (CVD) which are detected after Hodgkin Lymphoma therapy. II. To assess participants of AHOD1331 with t-CH for the presence or absence of objective signs of CVD using cardiac magnetic resonance imaging (MRI). SECONDARY OBJECTIVES: I. To assess whether participants in AHOD1331 with t-CH expand this population over time and possess objective findings of CVD. II. To assess whether patients both with and without objective findings of CVD using cardiac MRI possess clinical risk factors for CVD. EXPLORATORY OBJECTIVES: I. To assess the prevalence of patients receiving mediastinal radiation who have objective findings of CVD using cardiac MRI, that also possess t-CH with mutations associated with CVD. II. To assess whether specific patient characteristics and treatment (age, gender, race, dexrazoxane usage, etc.) correlate with a higher incidence of t-CH with mutations associated with CVD. III. To assess the effects of t-CH on CVD by considering other factors such as patient characteristics and clinical conditions associated with an elevated risk for CVD. OUTLINE: This is an observational study. Patients undergo collection of blood samples, complete surveys, and undergo cardiac MRI on study. Patients also have their medical records reviewed.
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 230 participants |
| Official Title : | Assessment of Clonal Hematopoiesis and Its Relationship to Cardiovascular Disease in Hodgkin Lymphoma Survivors |
| Actual Study Start Date : | 2023-08-18 |
| Estimated Primary Completion Date : | 2028-10-01 |
| Estimated Study Completion Date : | 2028-10-01 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 7 Years to 40 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
USA Health Strada Patient Care Center
Mobile, Albama, United States, 36604
RECRUITING
Phoenix Childrens Hospital
Phoenix, Arizona, United States, 85016
RECRUITING
Alfred I duPont Hospital for Children
Wilmington, Delaware, United States, 19803
RECRUITING
Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida, United States, 33908
RECRUITING
Arnold Palmer Hospital for Children
Orlando, Florida, United States, 32806
RECRUITING
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida, United States, 33607
RECRUITING
C S Mott Children's Hospital
Ann Arbor, Road cancer, United States, 48109
RECRUITING
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis, Minnesota, United States, 55404
RECRUITING
Washington University School of Medicine
Saint Louis, Missouri, United States, 63110
RECRUITING
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
RECRUITING
Albany Medical Center
Albany, New York, United States, 12208
RECRUITING
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
RECRUITING
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
RECRUITING
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
RECRUITING
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
RECRUITING
Oregon Health and Science University
Portland, Oregon, United States, 97239
RECRUITING
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
RECRUITING
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, United States, 15224
RECRUITING
East Tennessee Childrens Hospital
Knoxville, Tennessee, United States, 37916
RECRUITING
Cook Children's Medical Center
Fort Worth, Texas, United States, 76104
RECRUITING
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, United States, 77030
RECRUITING
Children's Hospital of San Antonio
San Antonio, Texas, United States, 78207
RECRUITING
Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8