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Clinical trials

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A Phase 2 Study of WU-CART-007, an Anti-CD7 Allogeneic CAR-T Cell Therapy inT-Cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

Study ID: NCT06514794
Start Date: 2024-12-13
End Date: 2028-12-30
Study Type

Interventional

Study Phase

Phase2

No. of Participants

125

Intervention / Treatment

WU-CART-007

Sponsor

Wugen, Inc.

Source: clinicaltrials.gov

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An Open Label Dose Escalation Study to Assess the Safety, Tolerability, and Pharmacologic Properties of High Dose Ambroxol Hydrochloride in Adult (≥ 18 Years of Age) Subjects With MPS III

Study ID: NCT06614894
Start Date: 2024-12-01
End Date: 2026-02-01
Study Type

Interventional

Study Phase

Phase3

No. of Participants

10

Intervention / Treatment

Ambroxol Hydrochloride 30 mg tablet - 9 mg/kg/day

Ambroxol Hydrochloride 30 mg tablet - 18 mg/kg/day

Ambroxol Hydrochloride 30 mg tablet - 27 mg/kg/day

Sponsor

Ozlem Goker-Alpan

Source: clinicaltrials.gov

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Testing a Precision Psychotherapy System for Low-income Patients

Study ID: NCT05118594
Start Date: 2026-02
End Date: 2026-11
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

111

Intervention / Treatment

Pre-treatment psychotherapy recommendations

Sponsor

National Council of Scientific and Technical Research, Argentina

Source: clinicaltrials.gov

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The Effects of Adding Expiratory Muscle Strength Training in Voice Therapy

Study ID: NCT03692494
Start Date: 2025-04-01
End Date: 2026-12-01
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

120

Intervention / Treatment

Standard of care voice therapy

Expiratory muscle strength training (EMST)

Sponsor

University of Miami

Source: clinicaltrials.gov

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EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation

Study ID: NCT06212791
Start Date: 2024-12-30
End Date: 2028-03
Study Type

Observational

Study Phase

Not Applicable

No. of Participants

50

Intervention / Treatment

Self- Report Evaluation-Duke Activity Status Index

Self- Report Evaluation Atrial Fibrillation Effect on Quality of Life Questionnaire

Cardiopulmonary exercise test (CPET)

Transthoracic echocardiogram

Ambulatory cardiac rhythm assessment

Cardiovascular magnetic resonance (CMR)

Sponsor

Virginia Commonwealth University

Source: clinicaltrials.gov

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Pip Care to Improve Surgical Patient Outcomes - Phase II

Study ID: NCT06661291
Start Date: 2025-02-01
End Date: 2028-09-01
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

1300

Intervention / Treatment

Pip Care Digital Health Platform

Standard of Care Protocol

Sponsor

University of Pittsburgh

Source: clinicaltrials.gov

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KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases

Study ID: NCT06451757
Start Date: 2025-01-02
End Date: 2027-07-02
Study Type

Interventional

Study Phase

Phase3

No. of Participants

150

Intervention / Treatment

Sonlicromanol

Placebo

Sponsor

Khondrion BV

Source: clinicaltrials.gov

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Ephedrine for Reducing Onset Time of Rocurinium in Elderly Patients

Study ID: NCT06681662
Start Date: 2024-12
End Date: 2025-12
Study Type

Interventional

Study Phase

Phase4

No. of Participants

80

Intervention / Treatment

Ephedrine Hydrochloride 30 mg/ml

Saline (NaCl 0,9 %) (placebo)

Sponsor

Matias Vested

Source: clinicaltrials.gov

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Switching From Dual Antiplatelet Therapy to Monotherapy With Potent P2Y12 Inhibitors

Study ID: NCT06691191
Start Date: 2025-01-01
End Date: 2026-12-31
Study Type

Interventional

Study Phase

Phase4

No. of Participants

48

Intervention / Treatment

Ticagrelor 90 mg

prasagrel 10 mug

Sponsor

University of Florida

Source: clinicaltrials.gov

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Retrospective Data Analysis with the Aim to Determine the Success Rate of Endotracheal Intubation in the First Attempt in the Zug Rescue Service with Various Airway Devices Already in Everyday Use: the Individual Complications Are to Be Examined Secondarily

Study ID: NCT06653166
Start Date: 2024-12-01
End Date: 2025-07-01
Study Type

Observational

Study Phase

Not Applicable

No. of Participants

200

Intervention / Treatment

bougie (S Guide)

videolaryngoscopy

Sponsor

Train rescue service

Source: clinicaltrials.gov

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