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Clinical trials for Parkinson Disease in United States

252 results

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A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Study ID: NCT06966700
Start Date: 2025-06-30
End Date: 2034-12-29
Study Type

Interventional

Study Phase

Phase3

No. of Participants

2400

Intervention / Treatment

Sacituzumab tirumotecan

Pembrolizumab

Rescue Medication

Carboplatin

Paclitaxel

Doxorubicin

Epirubicin

Cyclophosphamide

Capecitabine

Take it

Sponsor

Merck Sharp & Dohme LLC

Source: clinicaltrials.gov

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Phase 2 Trial of Tributyrin in People With Parkinson's Disease and Cognitive Impairments

Study ID: NCT07154511
Start Date: 2025-11-07
End Date: 2027-05
Study Type

Interventional

Study Phase

Phase2

No. of Participants

45

Intervention / Treatment

Tributyrin

Placebo

Sponsor

entrance canal

Source: clinicaltrials.gov

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KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

Study ID: NCT04165798
Start Date: 2019-12-19
End Date: 2032-02-13
Study Type

Observational

Study Phase

Not Applicable

No. of Participants

1065

Intervention / Treatment

Tumor Imaging

Tumor Tissue Collection

Blood Sample Collection

Sponsor

Merck Sharp & Dohme LLC

Source: clinicaltrials.gov

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Drug Discovery for Parkinson's With Mutations in the GBA Gene

Study ID: NCT05536388
Start Date: 2022-07-15
End Date: 2025-07-15
Study Type

Observational

Study Phase

Not Applicable

No. of Participants

60

Intervention / Treatment

Biological Sample Collection

Sponsor

New York Stem Cell Foundation Research Institute

Source: clinicaltrials.gov

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Retinal Imaging in Neurodegenerative Disease

Study ID: NCT03233646
Start Date: 2017-07-20
End Date: 2026-12-31
Study Type

Observational

Study Phase

Not Applicable

No. of Participants

2000

Intervention / Treatment

Retinal and Choroidal Imaging

Sponsor

Duke University

Source: clinicaltrials.gov

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Pyridostigmine for the Treatment of Constipation in Parkinson Disease

Study ID: NCT05603715
Start Date: 2022-08-10
End Date: 2026-12-31
Study Type

Interventional

Study Phase

Phase2

No. of Participants

16

Intervention / Treatment

Pyridostigmine Bromide

Sponsor

University of Vermont Medical Center

Source: clinicaltrials.gov

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Cognitive Decline Following Deep Brain Stimulation

Study ID: NCT05822388
Start Date: 2023-04-01
End Date: 2026-03-31
Study Type

Observational

Study Phase

Not Applicable

No. of Participants

80

Intervention / Treatment

Deep Brain Stimulation Surgical Procedures as Part of Routine Clinical Care

Sponsor

Medical University of South Carolina

Source: clinicaltrials.gov

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Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease

Study ID: NCT05968703
Start Date: 2025-04-08
End Date: 2027-07-31
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

10

Intervention / Treatment

Combined STN+NBM DBS

Sponsor

Helen M. Bronte-Stewart

Source: clinicaltrials.gov

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Globus Pallidus Stimulation to Treat Insomnia

Study ID: NCT04116996
Start Date: 2019-01-01
End Date: 2029-01-01
Study Type

Interventional

Study Phase

Not Applicable

No. of Participants

10

Intervention / Treatment

DEEP BRAIN STIMULATION

Sponsor

Mayo Clinic

Source: clinicaltrials.gov

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A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

Study ID: NCT07174310
Start Date: 2025-11-24
End Date: 2031-06-30
Study Type

Interventional

Study Phase

Phase3

No. of Participants

900

Intervention / Treatment

Prasinezumab

Placebo

Sponsor

Hoffmann-La Roche

Source: clinicaltrials.gov

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