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NCT07315997 | RECRUITING | Rheumatoid Arthritis (RA

The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study
Sponsor:

Brigham and Women's Hospital

Information provided by (Responsible Party):

Katherine P Liao

Brief Summary:

Individuals with rheumatoid arthritis (RA) have up to 2x the risk of having a heart attack compared to someone without RA. The goal of this study is to identify biomarkers that can help us do a better job of identifying individuals at risk before they develop symptoms of heart disease and start preventative treatment earlier.

Condition or disease

Rheumatoid Arthritis (RA

Atherosclerotic Cardiovascular Disease (ASCVD)

Intervention/treatment

high sensitivity cardiac troponin

Detailed Description:

The objective of this study is to test the utility of high sensitivity cardiac troponin (hs-cTn) and coronary artery calcium (CAC) in risk stratifying patients with rheumatoid arthritis (RA) who may benefit from lipid lowering therapy. The population of interest are individuals who would not otherwise be recommended for therapy based on general population risk calculators for heart disease risk.

Study Type : OBSERVATIONAL
Estimated Enrollment : 120 participants
Official Title : The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study
Actual Study Start Date : 2024-09-04
Estimated Primary Completion Date : 2028-03-04
Estimated Study Completion Date : 2028-03-04

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 35 Years to 79 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * RA diagnosed by a rheumatologist
  • * Age 40- 79
  • * ≥1 ASCVD risk factor including prediabetes, hypertension, BMI \>30, current or history of cigarette smoking
Exclusion Criteria
  • * Patients on a statin or with a contraindication to statin, on a cholesterol absorption inhibitor, or on a PCSK9 inhibitor
  • * Patients with diabetes mellitus
  • * Pregnancy
The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study

Location Details

NCT07315997

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Massachusetts

Brigham and Womens Hospital

Boston, Massachusetts, United States, 02115