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NCT07217782 | RECRUITING | Juvenile Idiopathic Arthritis

Pain in Juvenile Arthritis
Sponsor:

Washington University School of Medicine

Information provided by (Responsible Party):

Hadas nahman-Arverbuch

Brief Summary:

Juvenile idiopathic arthritis (JIA) is the most common rheumatologic disease in children. The main symptoms of JIA, which are often the primary focus of treatment, include joint swelling, stiffness, and tenderness. Additional symptoms can include malaise, fatigue, and pain. However, the exact mechanisms contributing to pain are not yet fully understood. Participants will complete a 2.5-hours study session. In the study session, psychophysical assessments of thermal and pressure stimuli will be performed. In addition, demographic, social, pubertal maturation, and behavioral and psychological factors will be collected via questionnaires. A saliva sample and/or blood draw may occur for the analysis of various immune factors and sex hormones. If a joint aspiration is done as part of their standard of care, we will request a sample of the synovial fluid for analyses of immune, hormonal and/or genetic factors. Participants will have the option to participate in additional optional follow-up study visits (every 3 months, up to 1 year) and to complete monthly surveys asking about their juvenile arthritis.

Condition or disease

Juvenile Idiopathic Arthritis

Intervention/treatment

Pressure pain thresholds (measured in kilopascal)

Cold pain tolerance (duration in seconds)

Phase

NA

Study Type : INTERVENTIONAL
Estimated Enrollment : 140 participants
Masking : NONE
Primary Purpose : OTHER
Official Title : Pain Processing Mechanisms in Patients With Juvenile Arthritis
Actual Study Start Date : 2025-09-15
Estimated Primary Completion Date : 2030-09
Estimated Study Completion Date : 2035-09

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 9 Years to 17 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • 1. Age between 9-17
  • 2. Males and females
  • 3. English speakers
  • 4. Able to complete surveys and understand study instructions
  • 5. Juvenile arthritis group: diagnosed or suspected of juvenile arthritis
  • 6. Control group: healthy
Exclusion Criteria
  • 1. Pregnancy or breastfeeding
  • 2. (Control Group) Diagnosed with a chronic pain condition
  • 3. (Control Group) Diagnosed with psychiatric condition including ADHD, anxiety, depression, etc.
Pain in Juvenile Arthritis

Location Details

NCT07217782

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How to Participate

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Locations

RECRUITING

United States, Missouri

Washington University School of Medicine

St Louis, Missouri, United States, 63017