Istanbul Health Sciences University
Ayşe Toraman
Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.
Periodontal Inflammation
Biofilm
Endothelial Dysfunction
Oral Bacteria
atheroma plaque
Dental plaque
Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream. Periodontal bacteria produce endotoxins in the form of lipopolysaccharide (LPS). Circulating LPS reacts with Toll-like receptors, promoting the production of reactive oxygen species and phagocytosis in the intima layer. Oxidative stress has been reported to be associated with mtDNA copy number.
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 55 participants |
| Official Title : | Periodontal Pathogens and Atherom Plaque The Number of Mitochondrial DNA Copies |
| Actual Study Start Date : | 2025-11-25 |
| Estimated Primary Completion Date : | 2026-08-01 |
| Estimated Study Completion Date : | 2026-12-01 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 25 Years to 90 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
Health Sciences University, Hamidiye Faculty of Dentistry, Department of Periodontology
Istanbul, Turkey (Türkiye),