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NCT07152912 | RECRUITING | Isoflurane

Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy
Sponsor:

Ain Shams University

Information provided by (Responsible Party):

Eman Adel Ali Abd Moaty

Brief Summary:

The primary aim of this work is to assess the impact of exposure to isoflurane or sevoflurane as an inhalation anesthetic on the oxidative stress and inflammatory conditions in patients undergoing elective moderate invasive surgery (laparoscopic cholecystectomy).

Condition or disease

Isoflurane

Sevoflurane

Oxidative Stress

Laparoscopic Cholecystectomy

Intervention/treatment

Isoflurane

Sevoflurane

Phase

NA

Detailed Description:

Oxidative stress is defined as "an imbalance between oxidants and antioxidants in favour of the oxidants, leading to a disruption of redox signalling and control and/or molecular damage. Isoflurane, which has been utilized since the 1980s, has a particularly low metabolism rate and solubility, leading to reduced induction of anesthesia during surgery and shortened recovery time after surgery. Sevoflurane began to be used a decade later and has a lower blood-gas partition coefficient than the other anesthetics, leading to rapid induction of anesthesia and fast awakening after anesthesia.

Study Type : INTERVENTIONAL
Estimated Enrollment : 80 participants
Masking : DOUBLE
Primary Purpose : TREATMENT
Official Title : A Comparative Study Between the Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy
Actual Study Start Date : 2025-09-04
Estimated Primary Completion Date : 2026-03-01
Estimated Study Completion Date : 2026-03-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 20 Years to 60 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Age from 20 to 60 years.
  • * Both sexes.
  • * American Society of Anesthesiologists (ASA) Physical Status I-II.
  • * Undergoing elective laparoscopic cholecystectomy under general anesthesia.
Exclusion Criteria
  • * Refusal of participation in the study by patients.
  • * Diabetes (type I or II), endocrine system, and immune system diseases.
  • * Chronic infection and sepsis.
  • * Cardiac condition as classified bythe New York Heart Association (NYHA) \> class II.
  • * Hepatic disease: INR \> 1.5, and/or albumin \< 2.5 g/dL.
  • * Renal disease: glomerular filtration rate (GFR) \< 85 ml/min.
  • * Mental and neurological disorders.
Impact of Isoflurane and Sevoflurane on Oxidative Stress in Patients Undergoing Laparoscopic Cholecystectomy

Location Details

NCT07152912

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Locations

RECRUITING

Egypt,

Ain Shams University

Cairo, Egypt, 11591