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NCT06943755 | RECRUITING | Pancreatic Neuroendocrine Tumor (pNET)

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
Sponsor:

EXELAXIS

Brief Summary:

The primary purpose of this study is to assess the effectiveness of zanzalintinib compared to everolimus in participants with previously treated, unresectable, locally advanced or metastatic neuroendocrine tumors.

Condition or disease

Pancreatic Neuroendocrine Tumor (pNET)

Extra-Pancreatic Neuroendocrine Tumor (epNET)

Intervention/treatment

Zanzalintinib

Everolimus

Phase

PHASE2

PHASE3

Study Type : INTERVENTIONAL
Estimated Enrollment : 440 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : A Phase 2/3, Multicenter, Randomized Open-Label Study of Zanzalintinib vs Everolimus in Participants With Previously Treated, Unresectable, Locally Advanced or Metastatic Neuroendocrine Tumors
Actual Study Start Date : 2025-07
Estimated Primary Completion Date : 2029-06
Estimated Study Completion Date : 2029-06

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Key Inclusion Criteria
  • * Histologically confirmed, locally advanced/unresectable or metastatic, well-differentiated Grade 1, 2, or 3 NETs of pancreatic origin or extra-pancreatic origin.
  • * Allowed prior lines of therapy, based on the site of NET and functional status.
  • * Documented radiographic disease progression per RECIST 1.1, as assessed by the Investigator based on imaging assessments (computed tomography \[CT\] or magnetic resonance imaging \[MRI\]) within 12 months before randomization.
  • * Measurable disease according to RECIST 1.1 as determined by the Investigator.
  • * Archival tumor tissue is required, if available. If archival tumor tissue is not available, a fresh biopsy may be submitted if it can be safely and feasibly obtained. Every attempt should be made to provide tumor tissue.
  • Key Exclusion Criteria
    • * Histologically confirmed neuroendocrine carcinomas (including small cell lung cancer), medullary thyroid cancer, pheochromocytoma, paraganglioma, Merkel cell carcinoma, and mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN).
    • * Prior treatment with a vascular endothelial growth factor receptor (VEGFR) -targeting tyrosine kinase inhibitor or a mammalian target of rapamycin (mTOR) inhibitor.
    • * Systemic chemotherapy and any liver-directed or other ablative therapy within 4 weeks before randomization.
    • * Systemic radionuclide therapy within 6 weeks before randomization.
    • * Radiation therapy for bone metastases within 2 weeks, any other radiation therapy, except as indicated above, within 4 weeks before randomization.
    • Note: Other protocol defined Inclusion/Exclusion criteria may apply.
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

Location Details

NCT06943755

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Road cancer

Evolution Clinical SEE #1

Grand Rapids, Road cancer, United States, 49546