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NCT06911931 | NOT YET RECRUITING | Schizophrenia Disorders

Visual Perception in Schizophrenia
Sponsor:

University of Rochester

Information provided by (Responsible Party):

Edmund Lalor

Brief Summary:

This study aims to identify novel markers of psychosis using electroencephalography (EEG).

Condition or disease

Schizophrenia Disorders

Bipolar Disorder

Schizoaffective disorder

Intervention/treatment

EEG measure of visual processing

Phase

NA

Study Type : INTERVENTIONAL
Estimated Enrollment : 84 participants
Masking : NONE
Primary Purpose : BASIC_SCIENCE
Official Title : Visual Perception in Schizophrenia: Assessing Predictive Processing in the Earliest Stages of the Visual Cortical Hierarchy
Actual Study Start Date : 2025-06-01
Estimated Primary Completion Date : 2027-01-31
Estimated Study Completion Date : 2027-01-31

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 65 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • * All Subjects
  • * Aged 18-65
  • * 20/32 visual acuity or better (using in-house optical correction, if necessary)
  • * An ability to speak English well enough to complete study assessments and to consent to the study
  • * Subjects with Schizophrenia-Spectrum Disorder
  • * Meets DSM-5 diagnostic criteria for schizophrenia, schizoaffective disorder, or schizophreniform disorder as confirmed by the Structured Interview for DSM-5 (SCID-5).
  • * Subjects with Bipolar Disorder
  • * Meets DSM-5 diagnostic criteria for bipolar disorder (type I, II, or unspecified) as confirmed by the Structured Interview for DSM-5 (SCID-5).
Exclusion Criteria
  • * All subjects
  • * Presence of characteristics that could impair one's ability to comprehend the nature of the study, provide informed consent, or understand the assessment questions, including the following
    • * Subject cannot read and understand the instructions well enough to complete the tasks or cannot provide informed consent.
    • * Intellectual impairment (WRAT-5 score \< 70) (at the discretion of experimenter);
    • * Actively intoxicated, as shown via patient self-report or staff report;
    • * Substance use disorder in the past 3 months;
    • * Subject considered high risk for suicidal acts (i.e., active suicidal ideation as determined by clinical interview OR any suicide attempt in 30 days prior to screening);
    • * Subject violence (involving severe/lethal means or violence occurring in prior 6 months) or extreme agitation.
    • * Being in a current manic state
    • * Head injury with loss of consciousness greater than 10 minutes (at the discretion of the experimenter).
    • * Subject has had electroconvulsive therapy (ECT) in the past 8 weeks;
    • * Diagnosed with a neurological condition (tumor, stroke, brain injury) or neurological disorder, including seizure disorders. Diagnosed with pervasive developmental disorder (phone screen or medical records)
    • * Lazy eye or squint or other known ocular pathology
    • * Healthy Control Subjects
    • * Any lifetime psychotic disorder or history of psychiatric hospitalization (self disclosure);
    • * Daily antidepressant, mood stabilizer or antipsychotic medication use in the last 6 months, or benzodiazepine use during the prior 2 days (self-disclosure); iii. First-degree relative(s) with a schizophrenia spectrum disorder (based on subject self-report) or bipolar disorder.
    • * Case-match Control Non-ill Subjects
    • * Any lifetime psychotic disorder (as assessed by SCID/or SSD);
    • * Recurrent depressive episodes or being in a current depressive episode (as assessed by SCID/or SSD)
    • * Persistent threshold psychotic symptoms
    • * History of psychiatric hospitalization;
    • * Daily antidepressant, mood stabilizer or antipsychotic medication use in the last 6 months, or benzodiazepine use during the prior 2 days
    • * First-degree relative(s) with a schizophrenia spectrum disorder (based on subject self-report) or bipolar disorder.
    • * Bipolar Subjects
    • * Persistent threshold psychotic symptoms
Visual Perception in Schizophrenia

Location Details

NCT06911931

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Not yet recruiting

United States, New York

University of Rochester

Rochester, New York, United States, 14642