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NCT06878430 | NOT YET RECRUITING | Covert Cerebrovascular Disease

Reducing Risk of Stroke and DementIa in PatientS with COVert CERebrovascular Disease
Sponsor:

University of Edinburgh

Brief Summary:

The purpose of the DISCOVER study is to pilot acceptable approaches to people with covert cerebrovascular disease (CCD) and their follow-up. This is the first step in designing efficient randomised trials of treatments to reduce the risk of stroke or dementia in people with CCD.

Condition or disease

Covert Cerebrovascular Disease

Intervention/treatment

Functional and Cognitive scores

Detailed Description:

DISCOVER is a prospective cohort involving individuals with covert cerebrovascular disease (CCD) in NHS Lothian. Participants will be recruited through electronic health records and clinician collaborators. Participants will be monitored at 3 and 6 months and where possible 12 months to assess cognitive, functional, and vascular event outcomes.

Study Type : OBSERVATIONAL
Estimated Enrollment : 100 participants
Official Title : Reducing Risk of Stroke and DementIa in PatientS with COVert CERebrovascular Disease: a Pilot and Development Study
Actual Study Start Date : 2025-06
Estimated Primary Completion Date : 2026-06
Estimated Study Completion Date : 2026-12

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 65 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * People who, at the time the letter is prepared or are identified by a clinician
  • * Age ≥ 65 years
  • * Have no known history of
    • * Stroke or TIA
    • * Dementia
    • * Parkinson's disease
    • * Multiple sclerosis
    • * Metastatic cancer (or non-meningioma brain tumour).
    • * A CT or MRI scan report ≤5 years before study start date with of one or more of
      • * Cerebral small vessel disease
      • * Deep old ischaemic stroke
      • * Cortical old ischaemic stroke
      Exclusion Criteria
      • * Text of brain scan report unreadable
      • * Do not consent to take part in study procedures
      • * Unable to consent
      • * Unable to communicate by email, letter or telephone through language, speech disability or lack of address
      • * Unlikely to survive one year past enrolment in judgement of the study investigator
Reducing Risk of Stroke and DementIa in PatientS with COVert CERebrovascular Disease

Location Details

NCT06878430

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

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