University hospitals KU Leuven
AIM: To investigate whether SV2A loss spreads from brainstem to cerebral cortex with progression of Parkinson's disease (PD) and to determine whether longitudinal cortical SV2A loss correlates with cognitive decline in PD. STUDY DESIGN: We will re-invite participants (both patients with PD and healthy controls) of a previous longitudinal study (NCT04243304, S61477) to undergo evaluation approximately 7 years after the initial baseline study visit (i.e. on average 10 years since the first motor symptoms). All participants will undergo clinical assessment of motor and non-motor symptoms (including cognitive testing), as well as 11C-UCB-J PET-CT (targeting synaptic density marker SV2A), 18F-FE-PE2I PET-CT (targeting DAT) and brain MRI.
Parkinson Disease
11C-UCB-J PET-CT
18F-PE2I PET-CT
MRI brain
NA
| Study Type : | INTERVENTIONAL |
| Estimated Enrollment : | 35 participants |
| Masking : | NONE |
| Primary Purpose : | DIAGNOSTIC |
| Official Title : | Longitudinal Measurement of Synaptic Loss and Cognitive Decline in the Long-term Course of Parkinson's Disease |
| Actual Study Start Date : | 2025-07 |
| Estimated Primary Completion Date : | 2027-12 |
| Estimated Study Completion Date : | 2027-12 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 30 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: | 1 |
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Not yet recruiting
UZ Leuven
Leuven, Belgium, 3000