Wake Forest University Health Sciences
The purpose of the study is to evaluate if firefighter exposure to hazardous compounds will increase the incidence of premalignant hematological states which subsequently increases the risk of the development of hematologic malignancies, and potentially other pathophysiological consequences.
Clonal Hematopoiesis of Indeterminate Potential
Monoclonal Gammopathy
Non Hodgkin Lymphoma
Leukemia
Multiple Myeloma
Plasma Cell Disorder
Monoclonal Gammopathy
Complete Blood Count with differential (CBC w/ diff)
Clonal hematopoiesis (CHIP)
Firefighters from the Charlotte Fire Department, ages 40-49 and with at least 5 years on the job experience will be offered consent for this study. Consented and eligible participants will have labs collected at the Baseline visit to evaluate for CHIP and monoclonal gammopathy. Buccal swabs (also collected at Baseline) and any remaining blood from the Baseline labs will be collected from participants who consent to collection and banking of their samples for future research. Participants will also complete the Firefighter History Assessment at Baseline. If clonal hematopoiesis (CHIP) results are interpreted by the investigator as abnormal, the participant will be given a clinical referral if indicated for discussion of diagnosis, potential further diagnostic tests, and implications per standard CHIP management guidelines. If monoclonal gammopathy or other (concerning) abnormality of the complete blood count is detected, the participant will be provided a referral for a clinic visit for diagnostic assessments and followed up per standard of care. If the participant proceeds with the referral and diagnostic work-up, the final diagnosis (if any) resulting from the initial diagnostic assessment(s) will be collected
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 300 participants |
| Official Title : | Pre-malignant States to Hematologic Malignancies in Firefighters |
| Actual Study Start Date : | 2025-04 |
| Estimated Primary Completion Date : | 2027-04 |
| Estimated Study Completion Date : | 2027-04 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 40 Years to 49 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: | 1 |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Not yet recruiting
Levine Cancer Institute
Charlotte, North Carolina, United States, 28204