University Hospital Hamburg-Eppendorf
Patients with a pouch frequently suffer from chronic inflammation of the intestinal tract, called pouchitis. Pouchitis is routienly treated with repeated courses of antibiotics and probiotics, which does not stop the inflammation from recurring and exposes the patients to the risk of developing antibiotic -resistant pouchitis. Experimental data suggest that the effectiveness of the antibiotic and probiotic treatment can be prolonged by high consumption of trypotophan, an aminoacid present in everyday food. The Try Pro Pouch study aims to compare the consumption of high amounts of tryptophan against placebo in patients with pouchitis.
Instigatis
Tryptophan 25mg/kg bodyweight
Placebo
NA
Participants with chronic pouchitis receive either a weight adapted supplement containing etiher trypotophan or a placebo after completing the standard treatment with antibiotics or probiotics for their pouchitis. Endoskopy will be performed, stool and blood will be sampled, symptoms will be monitored.
| Study Type : | INTERVENTIONAL |
| Estimated Enrollment : | 20 participants |
| Masking : | TRIPLE |
| Masking Description : | care providers, Investigators and Outcome Assessors are blinded. |
| Primary Purpose : | TREATMENT |
| Official Title : | Investigation of the influence of a diet -rich diet on the therapeutic potential of probiotics after antibiotic therapy for chronic pouchitis (Try Pro Pouch). A prospective randomized controlled double -blind intervention study |
| Actual Study Start Date : | 2025-04-01 |
| Estimated Primary Completion Date : | 2027-04-30 |
| Estimated Study Completion Date : | 2027-04-30 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
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