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NCT06858748 | NOT YET RECRUITING | Asthma

Canadian Consortium on Airway Mucus Occlusions in Asthma, COPD and Chronic Cough
Sponsor:

McMaster University

Brief Summary:

Chronic lung diseases affect one in five Canadians, causing symptoms such as cough, breathlessness, and wheeze. Despite advancements in medical care, these conditions not only impact individuals and their close circles but also present substantial clinical and economic challenges at a national level. This grant is dedicated to addressing three prevalent lung diseases: asthma, chronic obstructive pulmonary disease (COPD), and chronic cough. An alliance of clinicians, scientists, knowledge users, and patient partners from across Canada have come together to establish the Canadian Consortium for Understanding the Role of Airway Mucus Occlusions in Asthma, COPD, and Chronic Cough - "CANMuc." Mucus plays a pivotal role in the symptoms and severity of lung diseases, but its clinical assessment has been challenging. Fortunately, recent medical advances, particularly chest computed tomography (CT), facilitate visualizing and quantifying mucus in patients with lung diseases. Our goal is to initially assess mucus plugging in a diverse group of Canadians without lung disease and then compare these findings to those with asthma, COPD, and chronic cough. The investigators will recruit 100 healthy volunteers for comprehensive clinical and research evaluations, including sputum analyses, breathing tests, quality of life assessments, cough monitoring, and CT scans. In addition, testing will be conducted twice, two years apart, in 240 adult and 50 pediatric participants. This approach will enable the investigators to understand the burden of mucus and how it changes over time, explore proteins or chemicals in mucus that predict mucus persistence, and identify biomarkers that can help guide physicians to prescribe targeted treatments that might work better than others. The CANMuc team's findings will guide strategies for identifying and treating mucus plugging, inform policymakers, and share knowledge with Canadians living with asthma, COPD, and chronic cough.

Condition or disease

Asthma

Chronic Obstructive Pulmonary Disease (COPD)

Chronic Cough (CC)

Intervention/treatment

Observational

Study Type : OBSERVATIONAL
Estimated Enrollment : 240 participants
Official Title : Canadian Consortium for Understanding the Role of Airway Mucus Occlusions in Asthma, COPD and Chronic Cough
Actual Study Start Date : 2025-06
Estimated Primary Completion Date : 2027-12
Estimated Study Completion Date : 2028-04

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • * Males and females (≥18 years old)
  • Asthma: Respiratory physician confirmed diagnosis of moderate-to-severe asthma and Historical objective evidence of asthma and/or specialist/respirologist confirmation (post-bronchodilator reversibility and/or methacholine bronchoprovocation test \<8 mg/mL)
  • COPD: Respiratory physician confirmed diagnosis of COPD that is moderate-to-severe according to GOLD criteria (post-bronchodilator FEV1/FVC\
  • Chronic cough: Refractory Chronic Cough (RCC) and Unexplained Chronic Cough (UCC) lasting \>1 year with Normal chest radiograph and no airflow obstruction (FEV1/FVC \>Lower Limit of Normal)
  • Healthy participants: No history of respiratory disease or other pulmonary disorders and no use of inhaled medications or corticosteroids with normal spirometry and Modified Medical Research Council (mMRC) Dyspnea Scale =\<1
Exclusion Criteria
  • * Pregnant or breastfeeding
  • * Current smoker or \>10 yr pack history or smoked within the last 6 months
  • * Exacerbation within 4 weeks of recruitment
  • * Preterm birth (≤36 weeks gestation) or perinatal complications
  • * History of other pulmonary disorders
  • * Specialist/Respirologist suspects primary ciliary dyskinesia (PCD)
  • * Current use of mucolytic medications
  • * Memory, cognitive, or psychiatric limitations that may prevent optimal participation
  • * Treatment with current biologic therapy: anti-IgE mAb within 130 days, anti-IL-4/4R, IL-5/5R, IL-13, or TSLP within 2 months or 5 half-lives whichever is longer prior to visit 1
Canadian Consortium on Airway Mucus Occlusions in Asthma, COPD and Chronic Cough

Location Details

NCT06858748

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Not yet recruiting

Canada, British Columbia

St. Paul's Hospital

Vancouver, British Columbia, Canada, V6z 1y6

Not yet recruiting

Canada, Ontario

St. Joseph's Healthcare Hamilton

Hamilton, Ontario, Canada, L8N 4A6

Not yet recruiting

Canada, Ontario

Robarts Research Institute

London, Ontario, Canada, Release

Not yet recruiting

Canada, Ontario

The Ottawa Hospital

Ottawa, Ontario, Canada, K1h 8l6

Not yet recruiting

Canada, Quebec

Quebec Heart and Lung Institute - Laval University

Quebec City, Quebec, Canada, G1V 4G5

Not yet recruiting

Canada, Quebec

University of Sherbrooke

Sherbrooke, Quebec, Canada, J1H 5N4