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NCT06824818 | RECRUITING | Elderly

Study to Assess the Feasibility of Stopping Prostate Cancer Treatment Early in Elderly Patients
Sponsor:

University of Chicago

Brief Summary:

This study seeks to identify if it is feasible to stop Luteinizing Hormone-Releasing Hormone (LHRH) Agonist Therapy in elderly men with prostate cancer. We hypothesize that elderly prostate cancer patients on long term androgen ablation with LHRH agonists will be permanently castrated and do not require ongoing LHRH agonist therapy. Participants will be monitored by testosterone testing throughout study.

Condition or disease

Elderly

Prostate Cancer

Intervention/treatment

LHRH Agonist Therapy Discontinuation

Phase

NA

Study Type : INTERVENTIONAL
Estimated Enrollment : 155 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : A Feasibility Trial of LHRH Agonist Discontinuation in Elderly Prostate Cancer Patients
Actual Study Start Date : 2026-06
Estimated Primary Completion Date : 2026-12
Estimated Study Completion Date : 2027-06

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 70 Years
Sexes Eligible for Study: MALE
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Prostate cancer with \>3 years of LHRH agonist therapy.
  • * Age ≥70 years.
  • * ECOG performance status ≤2
  • * Baseline testosterone of \< 20 ng/ml
  • * No prior chemotherapy or Lu-PSMA (unless survival predictions are favorable).
  • * Ability to understand and sign informed consent.
Exclusion Criteria
  • * none
Study to Assess the Feasibility of Stopping Prostate Cancer Treatment Early in Elderly Patients

Location Details

NCT06824818

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Illinois

The University of Illinois at Chicago (UIC)

Chicago, Illinois, United States, 60607

NOT YET RECRUITING

United States, Illinois

UChicago Medicine Comprehensive Cancer Center

Chicago, Illinois, United States, 60637