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NCT06787066 | NOT YET RECRUITING | Menopause

Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms
Sponsor:

University of Missouri-Columbia

Information provided by (Responsible Party):

Jacqueline K Limberg, PhD

Brief Summary:

The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.

Condition or disease

Menopause

Intervention/treatment

Propranolol Hydrochloride

Phentolamine Injection

Phase

EARLY_PHASE1

Study Type : INTERVENTIONAL
Estimated Enrollment : 75 participants
Masking : NONE
Primary Purpose : BASIC_SCIENCE
Official Title : Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms
Actual Study Start Date : 2025-05
Estimated Primary Completion Date : 2026-12
Estimated Study Completion Date : 2026-12

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 70 Years
Sexes Eligible for Study: FEMALE
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • * Assigned female at birth
  • * 18-70 years of age
  • * Body mass index (BMI) \<30 kg/m2
Exclusion Criteria
  • * Assigned male at birth
  • * Pregnancy, breastfeeding
  • * Body mass index ≥30 kg/m2
  • * Oral hormonal contraception in last 6 months, history of hormone replacement therapy, oophorectomy
  • * Current smoking/nicotine use
  • * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
  • * Nerve/neurologic disease
  • * Cardiovascular, hepatic, renal, respiratory disease
  • * Blood pressure ≥140/90 mmHg
  • * Diabetes, Polycystic ovarian syndrome
  • * Communication barriers
  • * Prescription medications
Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms

Location Details

NCT06787066

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