Thinking of joining a study?

Register your interest

Become a volunteer?

NCT06751238 | RECRUITING | Juvenile Psoriatic Arthritis

Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability up to 6 Years of Intravenous (i.v.) Secukinumab in Pediatric Participants With Juvenile Psoriatic Arthritis (JPsA).
Sponsor:

Novartis Pharmaceuticals

Brief Summary:

The purpose of this study is to determine the PK, safety and tolerability of multiple doses of intravenous (i.v.) secukinumab in pediatric participants with JPsA

Condition or disease

Juvenile Psoriatic Arthritis

Intervention/treatment

Secukinumab

Phase

PHASE1

Detailed Description:

This is a multicenter, open-label study with an optional treatment extension period to evaluate pharmacokinetics, safety and tolerability (up to 6 years) of i.v. secukinumab in pediatric patients with JPsA.

Study Type : INTERVENTIONAL
Estimated Enrollment : 20 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : An Open-label, Multicenter Study to Evaluate Pharmacokinetics, Safety and Tolerability up to 6 Years of Intravenous Secukinumab Infusions in Pediatric Participants With Juvenile Psoriatic Arthritis
Actual Study Start Date : 2025-09-24
Estimated Primary Completion Date : 2032-11-30
Estimated Study Completion Date : 2032-12-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 2 Years to 17 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Key Inclusion Criteria
  • * Participants parent's or legal representative(s) written informed consent and child's assent, if appropriate, must be obtained before any study related activity or assessment is performed. Of note, if the participant reaches age of consent (as per local law) during the study, they will also need to sign the corresponding study ICF (Informed Consent Form).
  • * Males and females ≥2 years old to \<18 years old at the time of screening.
  • * Confirmed diagnosis of JPsA according to the modified International League of Associations for Rheumatology (ILAR) classification criteria that must have occurred at least 6 months prior to screening.
  • * Active JPsA disease defined as ≥3 active joints (swollen or if not swollen must be both tender and limited range of motion) at baseline (BSL).
  • * Inadequate response (≥1 month) or intolerance to ≥1 Non-Steroidal Anti-Inflammatory Drug (NSAID) at screening.
  • * Inadequate response (≥2 months) or intolerance to ≥ 1 Disease Modifying Anti-Rheumatic Drug (DMARD) at screening.
  • * Concomitant use of the following second-line agents such as disease-modifying and/or immunosuppressive drugs to treat the JPsA will be allowed
    • * Stable dose of methotrexate (MTX) (maximum of 20 mg/ m2 BSA/ week) for at least 4 weeks prior to the BSL visit, with folic/folinic acid supplementation (according to standard medical practice of the center).
    • * Stable dose of an oral corticosteroid (CS) at a prednisone equivalent dose of \<0.2 mg/kg/day or up to 10 mg/day maximum, whichever is less, for at least 7 days prior to BSL.
    • * Stable dose of no more than one NSAID for at least 1 week prior to BSL.
    • Key Exclusion Criteria
      • * Participants with body weight less than 10 kg at screening.
      • * Use of other investigational drugs within 4 weeks or 5 half-lives of BSL, or until the expected pharmacodynamic effect has returned to BSL, whichever is longer.
      • * History of hypersensitivity to study drug or its excipients or to drugs of similar chemical classes.
      • * Participants with active inflammatory bowel disease or active uveitis at screening or BSL.
      • * Fulfilling diagnostic criteria for any International League of Associations for Rheumatology (ILAR ) juvenile idiopathic arthritis (JIA) category other than JPsA at BSL.
      • * Participants treated with prohibited medication
      • * Participants taking any non-biologic DMARD at screening except for MTX.
      • * Any medical or psychiatric condition which, in the investigator's opinion, would preclude the participant from adhering to the protocol or completing the study per protocol.
      • Other inclusion/exclusion criteria may apply
Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability up to 6 Years of Intravenous (i.v.) Secukinumab in Pediatric Participants With Juvenile Psoriatic Arthritis (JPsA).

Location Details

NCT06751238

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Florida

University of Florida

Gainesville, florida, United States, 32610 8068

RECRUITING

United States, Illinois

Ann and Robert H Lurie Childs Hosp

Chicago, Illinois, United States, 60611

RECRUITING

United States, North Carolina

Levine Childrens Hospital

Charlotte, North Carolina, United States, 28203

RECRUITING

United States, Ohio

Univ Hosp Cleveland Medical Center

Cleveland, Ohio, United States, 44106-5028

RECRUITING

United States, Oregon

Legacy Emanuel Research Hosp Portland

Portland, Oregon, United States, 97232

RECRUITING

United States, Texas

Texas Arthritis Center

The Pass, Texas, United States, 79902