Loma Linda University
The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be uncomfortable and cause stress. The main questions this study aims to answer are: Does ETT suctioning raise pain levels as measured by the Critical-Care Pain Observation Tool (CPOT)? Does ETT suctioning increase certain chemicals in the blood (hypoxanthine, xanthine, and uric acid) that show stress and lack of oxygen in the body? Researchers will compare patients who have ETT suctioning (intervention group) with those who do not have suctioning during the study period (control group) to see if there are differences in pain and blood markers of stress. Participants will: Have pain measured before and after suctioning using the CPOT. Have blood samples taken from an existing line at three time points: 5 minutes before, 5 minutes after, and 30 minutes after suctioning. Provide demographic information (like age, gender, and diagnosis) from medical records. This research will help improve how pain is managed for ICU patients who cannot speak for themselves, potentially leading to better pain relief methods in the future.
Intensive Care Unit ICU
Intubation
Critical Illness
Mechanical Ventilation
Pain Measurement
Pain, Procedural
Oxidative Stress
Hypoxia
Biomarkers / Blood
Adult
Uric Acid
Sepsis
Covid
Influenza
Pneumonia
endotracheal tube suctioning
NA
| Study Type : | INTERVENTIONAL |
| Estimated Enrollment : | 110 participants |
| Masking : | SINGLE |
| Masking Description : | The lab technician who results the labs will be blinded. |
| Primary Purpose : | SUPPORTIVE_CARE |
| Official Title : | The Impact of Endotracheal Suctioning on Pain, Hypoxia, and Oxidative Stress Biomarkers in Intubated Adult ICU Patients: A Controlled Trial |
| Actual Study Start Date : | 2025-01-30 |
| Estimated Primary Completion Date : | 2025-04 |
| Estimated Study Completion Date : | 2026-01 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
Loma Linda University Medical Center Troesh Medical Campus
Loma Linda, California, United States, 92354