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NCT06682260 | NOT YET RECRUITING | Acute Heart Failure (AHF)

Evaluating the Effects of Nitroglycerin on Heart Function and Urinary Output in Patients with Acute Heart Failure
Sponsor:

Copenhagen University Hospital, Hvidovre

Information provided by (Responsible Party):

Frederick Lau

Brief Summary:

This study aims to understand how nitroglycerin affects patients with acute heart failure, a condition where the heart struggles to pump blood effectively, leading to fluid buildup and breathing difficulties. Nitroglycerin relaxes blood vessels to ease the heart's workload and may help reduce fluid buildup. The investigators hypothesize that nitroglycerin can increase blood flow from the heart and promote urine production, which may reduce congestion in AHF patients. By studying heart function, blood volume, and fluid levels during treatment, the goal is to identify which patients may benefit most from nitroglycerin therapy.

Condition or disease

Acute Heart Failure (AHF)

Intervention/treatment

Nitroglycerin (NTG)

Phase

PHASE4

Study Type : INTERVENTIONAL
Estimated Enrollment : 21 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : Impact of Nitroglycerin-induced Vasodilation on Stroke Volume and Diuretic Response in Acute Heart Failure: a Protocol for a Mechanistic Trial
Actual Study Start Date : 2025-01-01
Estimated Primary Completion Date : 2025-06-30
Estimated Study Completion Date : 2025-10-31

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Age ≥ 18 years
  • * Clinical diagnosis of AHF requiring hospitalization
  • * Systolic blood pressure ≥85 mmHg
  • * Echocardiographic signs of cardiac dysfunction, by at least one of
  • * Left ventricular ejection fraction ≤45%
  • * Abnormal left ventricular filling with dilatation of the left atrium
  • * Elevated filling pressures (systolic pulmonary artery pressure\>30, dilated vena cava inferior or E/é\>10)
  • * Significant left-sided heart valve disease
Exclusion Criteria
  • * Ongoing ventricular taky- or brady-arrythmias or supraventricular arrhythmias with heart rate \> 180 or \< 40 bpm.
  • * Retinopathy or intraocular lens implantation (contraindication to Valsalva maneuver)
  • * Recent myocardial infarction or thromboembolic events.
  • * Intake of sildenafil or vardenafil withing 24 h and tadalafil within 48 h.
  • * Absolute contraindication for vasodilation using nitroglycerin as assessed by treating physician
  • * Intravenous administration of furosemide within 2 hours of baseline measurements
Evaluating the Effects of Nitroglycerin on Heart Function and Urinary Output in Patients with Acute Heart Failure

Location Details

NCT06682260

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