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NCT06675357 | RECRUITING | Prostate Cancer Metastatic Disease

Using FAPI PET/MRI to Evaluate Prostate Cancer
Sponsor:

University of Wisconsin, Madison

Brief Summary:

The goal of this clinical trial is to gain more information about how FAPI (fibroblast activation protein inhibitor) binds to certain type of cells in the tumor tissue. The main question it aims to answer is how this information can be used to better diagnose and track prostate cancer. Participants will undergo two PET/MRI scans during two research visits, each of which may last up to 2.5 hours.

Condition or disease

Prostate Cancer Metastatic Disease

Prostate Cancers

Intervention/treatment

FAPI

Positron Emission Tomography (PET)

Magnetic Resonance Imaging

Phase

PHASE2

Study Type : INTERVENTIONAL
Estimated Enrollment : 30 participants
Masking : NONE
Primary Purpose : DIAGNOSTIC
Official Title : Novel FAP-targeted Approach to Metastatic Prostate Cancer
Actual Study Start Date : 2025-08
Estimated Primary Completion Date : 2026-12
Estimated Study Completion Date : 2026-12

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Age 18 years or older
  • * Able and willing to provide informed consent
  • * Known diagnosis of prostate cancer with established or suspected non-osseous, non-nodal metastases
  • * Scheduled for or recently performed (within 4 weeks) standard-of-care PSMA PET
  • * Optional: Scheduled for SOC biopsy of an established or suspected non-osseous, non-nodal metastases.
  • * Willing and able to undergo PET/MRI as part of this research
Exclusion Criteria
  • * Unable or unwilling to provide informed consent
  • * Contraindication(s) to or inability to undergo PET/MRI
  • * Participants for whom PET/MRI will delay timely delivery of treatment
  • * Participants requiring intravenous (IV) conscious sedation for imaging care; those requiring mild, oral anxiolytics for the clinical MRI will be allowed to participate as long as the following criteria are met:
  • * Have their own prescription for the medication
  • * The informed consent process is conducted prior to the self-administration of this medication
  • * Come to the research visit with a driver
Using FAPI PET/MRI to Evaluate Prostate Cancer

Location Details

NCT06675357

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Wisconsin

University of Wisconsin

Madison, Wisconsin, United States, 53705