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NCT06669117 | RECRUITING | Solid Tumor

FIH Trial of VERT-002 in Patients With Locally Advanced or Metastatic Solid Tumors With MET Alterations
Sponsor:

Pierre Fabre Medicine

Brief Summary:

The goal of this clinical trial is to investigate the safety, the activity of VERT-002 (PFL-002), and the optimal safe dose to be used, in participants with solid tumors including non-small cell lung cancer.

Condition or disease

Solid Tumor

MET Alteration

Intervention/treatment

VERT-002

Phase

PHASE1

PHASE2

Study Type : INTERVENTIONAL
Estimated Enrollment : 140 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : A First-In-Human (FIH) Phase I/II Open-label, Multicentre, Dose Escalation and Expansion Trial of VERT-002 in Patients With Locally Advanced or Metastatic Solid Tumors Including Non-small Cell Lung Cancer (NSCLC) Harboring Mesenchymal-Epithelial Transition (MET) Alterations
Actual Study Start Date : 2024-10-22
Estimated Primary Completion Date : 2030-10-21
Estimated Study Completion Date : 2032-10-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1. Part 1: histological confirmation of relapsed and/or refractory locally advanced or metastatic solid tumor for which no standard of care treatment is available.
  • 2. Part 2: histological confirmation of locally advanced or metastatic NSCLC Stage IIIB/C or IV (American Joint Commission on Cancer \[AJCC\] 8th edition) in participants who are not eligible for or should have received available standard of care therapies including curative intent surgery, chemoradiation, radiotherapy or systemic therapy.
  • 3. Part 1: presence of at least one of the following MET alterations based on local documentation of blood or archived tissue results
    • * METex14 mutation
    • * MET kinase domain activating gene mutations (e.g. H1094L/R/Y, D1228H/N/V, Y1230A/C/D/H)
    • * MET amplification
    • 4. Part 2-a: presence of METex14 mutation (based on local documentation of blood or archived tissue results) and for Part 2-b presence of at least one of the following MET alterations: METex14 mutation (based on local documentation of blood or archived tissue results), de novo MET amplification (based on local documentation of archived tissue results). Confirmation after enrollment in the trial will be performed by central testing from an archival tumor biopsy sample (either tissue block or at least 15 serial cut unstained slides of 5 μm, at least 20% tumor content). In case no archival biopsy is available for central testing, the patient must be willing to have a fresh tumor biopsy sample collected and the tumor biopsy should be deemed safe and feasible by the investigator.
    • 5. Part 2: at least one measurable target lesion according to RECIST v1.1.
    • 6. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.
    • 7. Part 1: participants may have received MET Tyrosine Kinase Inhibitor (TKI) as part of previous treatment, regardless of the line of therapy (first or second line), and regardless of the MET TKI being combined or not. Note: crizotinib will be considered a MET TKI.
    • 8. Part 2: a maximum of 3 prior lines of systemic therapies.
    • 9. Adequate hematologic function.
    • 10. Adequate hepatic function.
    • 11. Adequate renal function.
    • 12. Albumin ≥ 3 g/dL.
    • 13. Adequate coagulation function.
    • 14. Adequate cardiac function.
    • 15. Female participants of childbearing potential must have a negative highly sensitive serum β-HCG test performed within 7 days prior to the first dose of VERT-002 and a negative urine pregnancy test performed at C1D1 prior to the first dose of VERT-002.
    • 16. Male participants/partners with female spouse/partners of childbearing potential must agree to take appropriate precautions to avoid fathering a child.
    • NOTE: Other protocol defined inclusion criteria may apply.
    Exclusion Criteria
    • 1. Part 2: Documented evidence by local testing of targetable oncogene driver mutations.
    • 2. History of a primary malignancy other than the cancer under trial (as defined for Parts 1 and 2) with the exception of
      • * Participants with a previous malignancy who completed their anticancer treatment at least 2 years before signing informed consent and with no evidence of residual disease from the prior malignancy at screening.
      • * Malignancies with a negligible risk of metastasis or death (i.e. 5-year overall survival rate \> 90%) that are adequately treated.
      • 3. Uncontrolled Central Nervous System (CNS) metastases or spinal cord compression that are associated with progressive neurological symptoms or require increasing doses of corticosteroids to control the CNS disease.
      • 4. History of hypersensitivity to active or inactive ingredients of VERT-002, or drugs with a similar chemical structure or from a similar class.
      • 5. Active, bacterial, fungal, or viral infection, within 2 weeks prior to the first dose of VERT-002 (C1D1).
      • 6. Positive SARs-CoV-2 or variants of SARs-CoV2 test within 2 weeks prior to first dose administration of VERT-002 (C1D1) or with suspected infection with SARs-CoV-2 or variants of SARs-CoV-2 and confirmation pending.
      • 7. Impaired cardiovascular function or clinically significant cardiovascular disease (either active or within 6 months prior to signing main informed consent).
      • 8. Uncontrolled intercurrent illness including, but not limited to psychiatric illness or social situation that would limit compliance with trial requirements.
      • 9. Past medical history of Interstitial Lung Disease (ILD), drug induced ILD, radiation pneumonitis that requires steroid treatment, or any evidence of clinically active ILD.
      • 10. Women who are pregnant or breastfeeding.
      • 11. Prior anticancer therapy
        • * MET TKI within 7 days prior to the first dose of VERT-002,
        • * Any other systemic anticancer therapy within 28 days or 5 half-lives of the anticancer therapy whichever is the shortest, but with a minimum of 14 days interval, prior to the first dose of VERT-002 (C1D1),
        • * Radiotherapy to a large field or including a vital organ (including whole brain radiotherapy or stereotactic radiosurgery to brain) within 14 days prior to the first dose of VERT-002 (C1D1).
        • 12. Live attenuated vaccine within 28 days prior to the first dose of VERT-002 (C1D1).
        • 13. Any toxicities from prior therapy with NCI- CTCAE Grade \> 1 at the time of the first dose administration of VERT-002 (C1D1). Exceptions include any grade alopecia, fatigue and peripheral neuropathy with a grade ≤ 2.
        • 14. Major surgical procedure within 14 days of the first dose of VERT-002 (C1D1).
        • 15. Participation in a clinical trial with administration of an investigational drug within 5 half- lives plus 14 days of the investigational drug, prior to the first dose of VERT-002 (C1D1).
        • NOTE: Other protocol defined exclusion criteria may apply.
FIH Trial of VERT-002 in Patients With Locally Advanced or Metastatic Solid Tumors With MET Alterations

Location Details

NCT06669117

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, District of Columbia

Georgetown Lombardi Comprehensive Cancer Center

Washington D.C., District of Columbia, United States, 20007

RECRUITING

United States, Ohio

Gabrail Cancer Research Center

Canton, Ohio, United States, 44718

RECRUITING

United States, Tennessee

Sarah Cannon Research Institute Oncology Partners

Nashville, Tennessee, United States, 37203

RECRUITING

Belgium,

Institute Jules Bordet

Anderlecht, Belgium, 1070

RECRUITING

France,

APHP of Marseille - North Hospital

Marseille, France, 13915

RECRUITING

France,

Western Cancer Institute (ICO) - Saint-Herblain

Saint-Herblain, France, 44805

RECRUITING

France,

University Cancer Institute of Toulouse - Oncopole

Toulouse, France, 31100

RECRUITING

France,

Gustave Roussy

Villejuif, France, 94805

RECRUITING

Germany,

University of Cologne - Center for Integrated Oncology (CIO)

Cologne, Germany, 45147

RECRUITING

Germany,

Carl Gustav Carus University Hospital Dresden

Dresden, Germany, 1307

RECRUITING

Italy,

Hospital - San Luigi Gonzaga University

Orbassano, Italy, 10043

RECRUITING

Netherlands,

Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital

Amsterdam, Netherlands, 1066 CX

RECRUITING

South Korea,

Yonsei University College of Medicine

Seoul, South Korea, 03722

RECRUITING

South Korea,

Asan Medical Center (AMC)

Seoul, South Korea, 05505

RECRUITING

Spain,

12 de Octubre University Hospital

Madrid, Spain, 28041

RECRUITING

Spain,

La Paz University Hospital

Madrid, Spain, 28046

RECRUITING

Taiwan,

National Taiwan University Hospital

Taipei, Taiwan, 100225

RECRUITING

Taiwan,

Taipei Medical University Hospital

Taipei, Taiwan, 110

RECRUITING

Taiwan,

Taipei Veterans General Hospital

Taipei, Taiwan, 11217