Z HibinX U
Z HibinX U
This study investigates the causal relationship between allergic rhinitis and asthma using a bidirectional two-sample Mendelian randomization approach. Genetic data were derived from UK Biobank for allergic rhinitis and from Finnish biobank for asthma. This analysis aims to clarify the potential causal link between these two conditions.
Allergic Rhinitis
Asthma
Mendelian Randomization
This observational study utilizes a bidirectional two-sample Mendelian randomization (MR) analysis to examine the causal association between allergic rhinitis and asthma. The genetic data for allergic rhinitis were obtained from the UK Biobank, encompassing 18,934 cases and 64,595 controls, while asthma data were derived from a Finnish biobank, including 20,629 cases and 135,449 controls. The Mendelian randomization analysis was performed using inverse-variance weighting (IVW), Mendelian randomization-Egger (MR-Egger), and weighted median methods to ensure robust causal inference. Additional tests, such as Cochrane's Q test and Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO), were applied to assess heterogeneity and pleiotropy, enhancing the reliability of the findings. The results are expected to provide insights into the bidirectional causal relationship between allergic rhinitis and asthma, potentially informing future prevention and treatment strategies.
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 239607 participants |
| Official Title : | Bidirectional Mendelian Randomization Study Reveals Causal Associations Between Allergic Rhinitis and Asthma |
| Actual Study Start Date : | 2024-10-01 |
| Estimated Primary Completion Date : | 2024-10-15 |
| Estimated Study Completion Date : | 2024-10-28 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 0 Years |
| Sexes Eligible for Study: | ALL |
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Guangzhou Institute of Respiratory Diseases, the First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China, 510120