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NCT06644794 | NOT YET RECRUITING | Infertility, Female


Progesterone-modified Natural Cycle for FET
Sponsor:

Shandong University of Traditional Chinese Medicine

Information provided by (Responsible Party):

J ing-Y case song

Brief Summary:

Hormone replacement therapy (HRT) cycles, despite the ease of synchronizing embryo thawing and embryo transfer timing, increase the risk of pregnancies and obstetric complications compared to natural cycles (NC). By ensuring the presence of the corpus luteum while reducing the number of monitoring sessions, the progesterone modified natural cycle (P4mNC) offers more convenience for the patient than the normal NC. This study is designed to compare the effects of P4mNC and HRT cycles on FET outcomes.

Condition or disease

Infertility, Female

Intervention/treatment

Progesterone-modified natural cycle preparation for frozen embryo transfer

Hormone replacement therapy cycle preparation for frozen embryo transfer

Phase

PHASE3

Study Type : INTERVENTIONAL
Estimated Enrollment : 336 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : Comparison of Progesterone-modified Natural Cycle and Hormone Replacement Therapy Cycle for Endometrial Preparation in Single Frozen Blastocyst Transfer
Actual Study Start Date : 2024-12-05
Estimated Primary Completion Date : 2026-09-10
Estimated Study Completion Date : 2027-12-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 21 Years to 44 Years
Sexes Eligible for Study: FEMALE
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Patients aged 21 to 44 years undergoing FBT
  • * Body mass index (BMI) 18-35 kg/m2
  • * Having regular ovulatory cycles
Exclusion Criteria
  • * Untreated uterine adhesions
  • * Medical contraindications to estrogen and progesterone therapy
  • * Illnesses contraindicating assisted reproductive technology or pregnancy
  • * History of recurrent implantation failures (\> 2 embryo transfer failures)

Progesterone-modified Natural Cycle for FET

Location Details

NCT06644794


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