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NCT06640010 | RECRUITING | Hematopoietic and Lymphatic System Neoplasm

Using Induced-Pluripotent Stem Cells to Model Cancer Therapy-Related Adverse Events
Sponsor:

Mayo Clinic

Brief Summary:

This study is being done to find out if patient blood samples can be used to perform individualized modeling of cancer therapy-related side effects.

Condition or disease

Hematopoietic and Lymphatic System Neoplasm

Malignant Solid Neoplasm

Intervention/treatment

Non-Interventional Study

Detailed Description:

PRIMARY OBJECTIVES: I. Generate induced pluripotent stem cells (iPSC's) from patients receiving cancer treatment. II. Differentiate patient iPSC's into cardiomyocytes and/or neurons or other cell types that may be relevant to modeling cancer therapy-related adverse effects, such as cardiotoxicity and neurotoxicity. III. Use patient specific iPSC-derived cells to: IIIa. Model cancer therapy-related toxicities; IIIb. Better understand the mechanisms of toxicities; IIIc. Determine if patient specific genetic variants are causative of toxicities; IIId. Screen novel protective therapies for cancer therapy-related toxicities. OUTLINE: This is an observational study. Patients undergo blood sample collection and have their medical records reviewed on study.

Study Type : OBSERVATIONAL
Estimated Enrollment : 30 participants
Official Title : Using Induced-Pluripotent Stem Cells to Model Cancer Therapy-Related Adverse Events
Actual Study Start Date : 2025-01-13
Estimated Primary Completion Date : 2025-12-15
Estimated Study Completion Date : 2026-12-15

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * \* Any patient \>= 18 years of age
  • * Planned or receiving any potentially toxic cancer therapy including but not limited to chemotherapy, targeted and immunotherapies
Exclusion Criteria
  • * Inability on the part of the patient to understand the informed consent or be compliant with the protocol
Using Induced-Pluripotent Stem Cells to Model Cancer Therapy-Related Adverse Events

Location Details

NCT06640010

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Florida

Mayo Clinic in Florida

Jacksonville, Florida, United States, 32224-9980