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NCT06623474 | RECRUITING | Hepatocellular Carcinoma

Correlation Study of Lipid Metabolites as Markers of Hepatocellular Carcinoma
Sponsor:

Nanfang Hospital, Southern Medical University

Brief Summary:

As one of the common malignant tumors in China, primary liver cancer, whose incidence rate and mortality rate are always in the top five, is seriously threatening the health of people. Therefore, early diagnosis and treatment of primary liver cancer are of great significance. In recent years, the incidence of primary liver cancer, which is caused by hepatic steatosis or metabolic dysfunction-related liver disease, is increasing year by year, and it has become one of the fastest rising causes in some developed countries. More and more studies have also confirmed that the levels of different kinds of lipids and their metabolites are correlated with the development of hepatocellular carcinoma. In this study, the researchers performed qualitative and quantitative analyses of various common lipid metabolites in plasma and liver cancer tissues of hepatic resection patients with hepatocellular carcinoma, collected tumor-related pathological data from the patients, and investigated the correlation between the lipid metabolites and the development of hepatocellular carcinoma, in order to provide a new idea for the early diagnosis and treatment of primary hepatocellular carcinoma, as well as for screening of hepatocellular carcinoma markers.

Condition or disease

Hepatocellular Carcinoma

Intervention/treatment

diagnosed by traditional diagnostic markers（such as AFP or CT etc.）

Study Type : OBSERVATIONAL
Estimated Enrollment : 900 participants
Official Title : Correlation Study of Lipid Metabolites as Markers of Hepatocellular Carcinoma
Actual Study Start Date : 2024-07-01
Estimated Primary Completion Date : 2032-06-30
Estimated Study Completion Date : 2032-07-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 80 Years
Sexes Eligible for Study: ALL
Criteria
Inclusion Criteria
  • * Patients aged 18-80 years old undergoing hepatic resection for hepatocellular carcinoma (diagnostic criteria for hepatocellular carcinoma refer to the guidelines for the diagnosis and treatment of primary hepatocellular carcinoma).
  • * Voluntary signing of informed consent
Exclusion Criteria
  • * In the judgment of the investigator, they are not suitable to participate in this study.
  • * Patients with hepatic malignant tumors with invasion of the main portal vein and its first-order branches, the common hepatic duct and its first-order branches, the main hepatic vein and the inferior vena cava, or extrahepatic metastases.
  • * Surgery with biliary tract exploration or reconstruction in the presence of biliary obstruction.
  • * Surgery combined with splenectomy or splenic artery ligation
  • * Preoperative combination of cardiac, pulmonary, renal and other organs with major underlying diseases.
Correlation Study of Lipid Metabolites as Markers of Hepatocellular Carcinoma

Location Details

NCT06623474

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Locations

RECRUITING

China, Guangdong

Nanfang Hospital

Guangzhou, Guangdong, China, 510515