University of Louisville
arthur malkani
The goal of this clinical trial is to learn if preparing the target alignment of the operative side in total knee arthroplasty (TKA) based on the non-arthritic side will give the patient better overall alignment, function, and improved results compared to basing our implant alignment and positioning off the arthritic side, which is currently the traditional method. The main questions it aims to answer are: * Will a patient have improved postoperative TKA results if the implant alignment is based off the non-arthritic side compared to the standard arthritic side? * What are the similarities or differences between study arms with respect to final implant alignment and positioning angles? Researchers will compare the outcomes of two cohorts of patients undergoing primary robotic-assisted total knee arthroplasty (RA-TKA) with normal contralateral knee. Based on preoperative CT imaging, the researchers will use normal contralateral side joint numbers as the target alignment for one group (Experimental arm) and utilize the traditional method for the other group (Active comparator arm). Clinical outcomes and patient-reported outcome measures (PROMs) will be compared between groups. Participants will: * Be randomized into one of two study arms and will receive either a unilateral knee CT or bilateral knee CT preoperatively * Follow-up in the clinic at 2 weeks, 6 weeks and 1-year postoperatively, per standard-of-care for x-ray and clinical evaluation. * Complete postop questionnaires (PROMs) at the prescribed follow-up intervals
Osteoarthritis (OA) of the Knee
CT scan unilateral knee
CT scan bilateral knee
NA
Study Type : | INTERVENTIONAL |
Estimated Enrollment : | 200 participants |
Masking : | NONE |
Primary Purpose : | BASIC_SCIENCE |
Official Title : | Native Alignment in the Setting of an Arthritic Knee in Total Knee Arthroplasty |
Actual Study Start Date : | 2024-11-07 |
Estimated Primary Completion Date : | 2026-04-30 |
Estimated Study Completion Date : | 2026-05-31 |
Information not available for Arms and Intervention/treatment
Ages Eligible for Study: | 21 Years to 89 Years |
Sexes Eligible for Study: | ALL |
Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Not yet recruiting
UofL Health
Louisville, Kentucky, United States, 40202