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NCT06596694 | RECRUITING | Gastrointestinal Cancer

Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)
Sponsor:

Merck Sharp & Dohme LLC

Brief Summary:

Researchers want to learn if patritumab deruxtecan (MK-1022) can treat certain gastrointestinal (GI) cancers. The GI cancers being studied are advanced (the cancer has spread to other parts of the body). The goals of this study are to learn: * About the safety and how well people tolerate of patritumab deruxtecan * How many people have the cancer respond (get smaller or go away) to treatment

Condition or disease

Gastrointestinal Cancer

Intervention/treatment

Patritumab deruxtecan

Phase

PHASE1

PHASE2

Study Type : INTERVENTIONAL
Estimated Enrollment : 130 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : A Phase 1/2 Study to Evaluate the Safety and Efficacy of Patritumab Deruxtecan in Gastrointestinal Cancers
Actual Study Start Date : 2024-11-03
Estimated Primary Completion Date : 2028-07-24
Estimated Study Completion Date : 2028-07-24

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • The main inclusion criteria include but are not limited to the following
    • * Has one of the following cancers
      • * Unresectable or metastatic colorectal cancer.
      • * Advanced and/or unresectable biliary tract cancer (BTC)
      • * Hepatocellular carcinoma (HCC) not amenable to locoregional therapy
      • * Has received prior therapy for the cancer.
      • * Has recovered from any side effects due to previous cancer treatment
      Exclusion Criteria
      • The main exclusion criteria include but are not limited to the following
        • * Has a history of (noninfectious) interstitial lung disease (ILD)/pneumonitis that required steroids, or has current ILD/pneumonitis, and/or suspected ILD/pneumonitis that cannot be ruled out by standard diagnostic assessments at Screening
        • * Has clinically severe respiratory compromise (based on the investigator's assessment) resulting from intercurrent pulmonary illnesses
        • * Has evidence of any leptomeningeal disease
        • * Has clinically significant corneal disease
        • * Has uncontrolled, significant cardiovascular disease or cerebrovascular disease
        • * Has evidence of ongoing uncontrolled systemic bacterial, fungal, or viral infection
Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)

Location Details

NCT06596694

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, California

UCLA Hematology Oncology Santa Monica ( Site 1205)

Santa Monica, California, United States, 90404

RECRUITING

United States, District of Columbia

Sibley Memorial Hospital ( Site 1208)

Washington, District of Columbia, United States, 20016

RECRUITING

United States, Florida

University of Florida ( Site 1202)

Gainesville, Florida, United States, 32610

RECRUITING

United States, Florida

Mount Sinai Medical Center Comprehensive Cancer Center ( Site 1213)

Miami Beach, Florida, United States, 33140

RECRUITING

United States, Georgia

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 1203)

Marietta, Georgia, United States, 30060

RECRUITING

United States, Illinois

University of Chicago Medical Center ( Site 1204)

Chicago, Illinois, United States, 60637

RECRUITING

United States, Nevada

Renown Regional Medical Center ( Site 1221)

Reno, Nevada, United States, 89502

RECRUITING

United States, New York

NYU Langone Hospital - Long Island ( Site 1230)

Mineola, New York, United States, 11501

RECRUITING

United States, New York

Perlmutter NYU Cancer Center ( Site 1212)

New York, New York, United States, 10016

RECRUITING

United States, Virginia

Oncology and Hematology Associates of Southwest Virginia (BRCC) ( Site 1207)

Roanoke, Virginia, United States, 24014

RECRUITING

United States, Wisconsin

University of Wisconsin ( Site 1210)

Madison, Wisconsin, United States, 53792

RECRUITING

Australia, New South Wales

Westmead Hospital ( Site 0100)

Sydney, New South Wales, Australia, 2145

RECRUITING

Australia, Victoria

Alfred Health ( Site 0102)

Melbourne, Victoria, Australia, 3004

RECRUITING

Australia, Victoria

Austin Health ( Site 0103)

Melbourne, Victoria, Australia, 3084

RECRUITING

Australia, Western Australia

One Clinical Research ( Site 0104)

Mount Pleasant, Western Australia, Australia, 6009

RECRUITING

Canada, New Scotia

QEII Health Sciences Centre - Victoria General Site ( Site 0200)

Halifax, Nova Scotia, Canada, He was cut off

RECRUITING

Chile, Region M. Of Santiago

Arturo Lopez Perez Foundation (Site 0301)

Santiago., Region M. Of Santiago, Chile, 7500921

RECRUITING

Chile, Region M. Of Santiago

Precision Oncology Center (Site 0305)

Santiago, Region M. Of Santiago, Chile, 7560908

RECRUITING

Chile, Region M. Of Santiago

UC San Carlos de Apoquindo Clinic (Site 0302)

Santiago, Region M. Of Santiago, Chile, 7620002

RECRUITING

Chile, Region M. Of Santiago

Bradfordhill ( Site 0300)

Santiago, Region M. Of Santiago, Chile, 8420383

RECRUITING

China, Anhui

The First Affiliated Hospital of Anhui Medical University ( Site 0405)

Fairy, Anhui, China, 230022

RECRUITING

China, Fujian

Fujian Provincial Cancer Hospital ( Site 0408)

F U-axis, Fujian, China, 350014

RECRUITING

China, Fujian

ZHongshan hospital F U egg university (ξ Amen branch) ( site 0412)

Xiamen, Fujian, China, 361015

RECRUITING

China, Guangdong

Southern Medical University Nanfang Hospital ( Site 0413)

F U-axis, Guangdong, China, 510515

RECRUITING

China, Guangxi

Affiliated Cancer Hospital of Guangxi Medical University ( Site 0411)

Nanning, Guangxi, China, 530201

RECRUITING

China, Henan

Henan Cancer Hospital ( Site 0403)

Zhengzhou, Henan, China, 450008

RECRUITING

China, Shanghai

Z Hongshan Hospital, F U egg university ( site 0400)

Shanghai, Shanghai, China, 200032

RECRUITING

China, Shanxi

First Hospital of Shanxi Medical University ( Site 0409)

Tai Yuan, Shanxi, China, 030001

RECRUITING

France, Hauts-de-Seine

Beaujon hospital (site 0500)

Clichy, Hauts-de-Seine, France, 92110

RECRUITING

France, Ille-et-Vilaine

Center Eugène Marquis Rennes - Cancer fighting center (site 0501)

Rennes, Ille-et-Vilaine, France, 35042

RECRUITING

France, Rhone-Alpes

Hospital of the Rousse Cross (site 0502)

Lyon, Rhone-Alpes, France, 69004

RECRUITING

Israel,

Rambam Health Care Campus ( Site 0603)

Haifa, Israel, 3109601

RECRUITING

Israel,

Sourasky Medical Center ( Site 0601)

Tel Aviv, Israel, 6423906

RECRUITING

Israel,

Hadassah Medical Center ( Site 0602)

Yerushalayim, Israel, 9112001

RECRUITING

Italy,

IRCCS Foundation National Cancer Institute (Site 0700)

Milano, Italy, 20133

RECRUITING

Italy,

ASST Grande Metropolitan Hospital Niguarda (Site 0701)

Milano, Italy, 20162

RECRUITING

Italy,

Agostino Gemelli Polyclinic University Foundation (Site 0702)

Roma, Italy, 00168

RECRUITING

Korea, Republic of, Seoul

Seoul National University Hospital ( Site 0900)

SEODAEMEN-GUE, Seoul, Korea, Republic of, 03080

RECRUITING

Korea, Republic of,

Severance Hospital, Yonsei University Health System ( Site 0903)

Seoul, Korea, Republic of, 03722

RECRUITING

Korea, Republic of,

Asan Medical Center ( Site 0902)

Seoul, Korea, Republic of, 05505

RECRUITING

Korea, Republic of,

Samsung Medical Center ( Site 0901)

Seoul, Korea, Republic of, 06351

RECRUITING

New Zealand,

Harbour Cancer & Wellness ( Site 0800)

Auckland, New Zealand, 1023

RECRUITING

Spain, Asturias

Central Hospital of Asturias (Site 1001)

Oviedo, Asturias, Spain, 33011

RECRUITING

Spain,

Vall d'Hebron University Hospital (Site 1000)

Barcelona, Spain, 08035

RECRUITING

Spain,

Gregorio Maranon University Hospital (Site 1002)

Madrid, Spain, 28007

RECRUITING

Spain,

San Carlos Clinic Hospital ... (Site 1003)

Madrid, Spain, 28040

RECRUITING

Switzerland,

University hospital of Geneva Hug. (Site 1102)

Genetic, Switzerland, 1211

RECRUITING

Switzerland,

Universitaetsspital Zuerich ( Site 1105)

Zurich, Switzerland, 8091

RECRUITING

Taiwan,

National Cheng If University Hospital-Clinical Trial Center (site 1502)

Tainan, Taiwan, 704

RECRUITING

Taiwan,

National Taiwan University Hospital ( Site 1500)

Taipei, Taiwan, 10002

RECRUITING

Taiwan,

Taipei Veterans General Hospital ( Site 1501)

Taipei, Taiwan, 112201

RECRUITING

Thailand, Thep Thep Thep Mahachon

Faculty of Medicine Siriraj Hospital ( Site 1301)

Bangkoknoi, The Thep Thep Maha Nakhon, Thailand, 10700

RECRUITING

Thailand, Thep Thep Thep Mahachon

Ramatibodi Hospital (Site ౧౩౦౨)

Rach, The Thep Thep Maha Nakhon, Thailand, 10400

RECRUITING

Turkey,

Hacettepe University Hospitals (Site 1401)

Ankara, Turkey, 06230