TScan Therapeutics, Inc.
The most clinically meaningful way to discover new targets of T cells in autoimmune diseases is to study the tissues of patients with active autoimmune disease mediated organ inflammation. These tissues contain both cytotoxic and helper T cells that are driving their disease, and these T cells are being guided by TCRs that recognize tissue-specific targets. By collecting tissue when a patient has active inflammation, it is possible to determine which T cells are activated and undergoing clonal expansion in the patient's diseased organ. TScan has developed a genome-wide, high-throughput technology to determine the natural, physiological target of any TCR (Kula, 2019). The goal of this study is to isolate T cells from inflamed tissues and matched blood samples and/or matched normal tissues (for patients with inflammatory bowel diseases). T cell clones that are expanded in diseased tissues relative to blood or normal tissues will be selected and the targets of their TCRs will be defined using TScan's genome-wide, high-throughput target ID technology. The goal of this study is to discover a collection of peptide targets, along with their associated TCRs to be developed as new tolerogenic therapies for patients with autoimmune diseases.
Autoimmune Diseases
Ulcerative Colitis
Multiple Sclerosis
Scleroderma
Ankylosing Spondylitis
Celiac Disease
Non-radiographic Axial Spondyloarthritis (nr-axSpA)
Crohn's Disease
Birdshot Chorioretinitis
Companion blood samples with procedure
Study Type : | OBSERVATIONAL |
Estimated Enrollment : | 300 participants |
Official Title : | A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients with Autoimmune Disease |
Actual Study Start Date : | 2023-01-03 |
Estimated Primary Completion Date : | 2025-01 |
Estimated Study Completion Date : | 2025-06 |
Information not available for Arms and Intervention/treatment
Ages Eligible for Study: | 18 Years |
Sexes Eligible for Study: | ALL |
Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
Arizona Arthritis & Rheumatology, PLLC
Phoenix, arizona, United States, 85032
RECRUITING
Inland Empire Gastroenterology
Murrieta, California, United States, 92562
RECRUITING
Knowledge Research Center
Orange, California, United States, 92868
RECRUITING
Cura Clinical Research
Sherman Oaks, California, United States, 91403
RECRUITING
Neurostudies, LLC
Port Charlotte, Florida, United States, 33952
NOT YET RECRUITING
Rheumatology of Central Indiana
Muncie, Indiana, United States, 47304
RECRUITING
University of Kentucky Research Foundation
Lexington, Kentucky, United States, 40536
RECRUITING
Gastroenterology Group of Rochester
Rochester, New York, United States, 14618
RECRUITING
Great Lakes Gastroenterology Research, LLC
Mentor, Ohio, United States, 44060
RECRUITING
Digestive Disease Specialists, Inc
Oklahoma City, Oklahoma, United States, 73112
RECRUITING
Susquehanna Research Group
Harrisburg, Pennsylvania, United States, 17110
RECRUITING
Nexus Research
Cranston, Rhode Island, United States, 02920
RECRUITING
Nexus Research
Cranston, Rhode Island, United States, 02920
RECRUITING
Nexus Research
Cranston, Rhode Island, United States, 02920
RECRUITING
Nexus Research
Cranston, Rhode Island, United States, 02920
RECRUITING
Nexus Research
Cranston, Rhode Island, United States, 02920
RECRUITING
University Gastroenterology
Providence, Rhode Island, United States, 02904
RECRUITING
Palmetto Gastroenterology Clinical Research, LLC
Summerville, South Carolina, United States, 29486
RECRUITING
Advanced Gastroenterology
Union City, Tennessee, United States, 38261
RECRUITING
Novel Research
Bellaire, Texas, United States, 77401
RECRUITING
GI Research Partners, LLC
Chesterfield, Virginia, United States, 23236
RECRUITING
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226