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NCT06585072 | RECRUITING | Pancreatic Cancer

Pancreatic Cancer and Diabetes Mellitus
Sponsor:

Shanghai Changzheng hospital

Information provided by (Responsible Party):

TU OL i, MD

Brief Summary:

The goal of this observational study is to learn about post-surgery of pancreatic cancer diabetes mellitus.The main questions it aims to answer are: 1. Are the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) after pancreatic cancer of different etiologies the same? 2. Are alterations in endocrine and exdocrine secretory function in patients with pancreatic surgery associated with all-round outcomes? All patients with pancreatic surgery have been given the standardized treatment for the condition. The reasearchers will summarize the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) during different surgical procedures to explore the association between alternations in endocrine and exdocrine secrectory function and all-round outcomes.

Condition or disease

Pancreatic Cancer

Surgery

Diabetes Mellitus

Intervention/treatment

All enrolled subjects completed dynamic blood glucose monitoring to obtain continuous peripheral blood glucose data.

Detailed Description:

Investigators will prospectively collect data from patients with pancreatic cancer after surgery in participant centers.

Study Type : OBSERVATIONAL
Estimated Enrollment : 150 participants
Official Title : Prospective Cohort Study on Endo-Exdo Secretory Function Alterations and All-round Outcomes After Pancreatic Cancer
Actual Study Start Date : 2025-01-03
Estimated Primary Completion Date : 2026-09-01
Estimated Study Completion Date : 2026-09-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1\. male or female Chinese subjects; 2. Age ≥ 18 years; 3. patients with pancreatic cancer who are proposed to undergo pancreatectomy by pancreaticobiliary surgery at our hospital; 4. those who voluntarily completed the Pancreatobiliary Surgery Cohort Study and signed the informed consent; 5. those who have completed and banked serum and pathological specimens at our hospital.
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Exclusion Criteria
  • 1\. those with a previous history of comorbid diabetes mellitus or pre-diabetes mellitus, or preoperative HbA1C ≥ 6.0% or fasting blood glucose ≥ 6.1 mmol/l; 2. those with positive islet-associated antibodies 3. those with the presence of medications, endocrine disease exposures that can lead to a risk of secondary diabetes; 4. pregnant or nursing women; 5. Cognitive impairment or other reasons for failing to sign the informed consent form.
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Pancreatic Cancer and Diabetes Mellitus

Location Details

NCT06585072

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Locations

RECRUITING

China, Shanghai Municipality

Changzheng hospital

Shanghai, Shanghai Municipality, China, 200003