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NCT06567561 | RECRUITING | Cancer

IGNITE Firefighters' Health
Sponsor:

Stanford University

Information provided by (Responsible Party):

Christopher Gardner

Brief Summary:

Investigators hope to learn about potential dietary intervention strategies (specifically a whole-food, plant-based diet) that may help lower cancer markers in firefighters.

Condition or disease

Cancer

Inflammation

Microbiome

Immune Function

Intervention/treatment

Whole Foods Plant-Based Diet

Usual Firehouse Diet

Phase

NA

Detailed Description:

The purpose of the San Francisco (SF) Firefighter's Diet Study is to determine if a diet low in processed foods, mostly plant-based, with added fermented foods, can lower the risk of cancer in firefighters. We will assess this by randomly assigning SF firefighters to either a whole-food, plant-based diet or their usual firehouse meals. Participants will be followed for 12 weeks.

Study Type : INTERVENTIONAL
Estimated Enrollment : 120 participants
Masking : NONE
Primary Purpose : PREVENTION
Official Title : Implementing Good Nutrition to Improve, Transform, and Enhance Firefighters' Health
Actual Study Start Date : 2025-01-09
Estimated Primary Completion Date : 2025-12-30
Estimated Study Completion Date : 2025-12-30

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Inclusion Criteria
  • * Age 18+
  • * Active SF firefighter
  • * Willing to consume a plant-based diet (vegetables, fruit, whole grains, legumes, etc.)
  • * Willing to complete 4 clinic visits
Exclusion Criteria
  • * Weight \< 110 lb
  • * BMI \>= 40
  • * Self-reported uncontrolled hypercholesterolemia, hypertension or diabetes
  • * Pregnant, lactating, or planning to become pregnant during the course of the study.
  • * Use of any of the following drugs/supplements within the last 2 months
    • * systemic antibiotics, antifungals, antivirals, or antiparasitics (intravenous, intramuscular, or oral);
    • * corticosteroids (intravenous, intramuscular, oral, nasal or inhaled);
    • * cytokines;
    • * methotrexate or immunosuppressive cytotoxic agents.
    • * Chronic, clinically significant, or unstable (unresolved, requiring ongoing changes to medical management or medication) pulmonary, cardiovascular, gastrointestinal, hepatic or renal functional abnormality, as determined by medical history, Type 1 diabetes, dialysis
    • * History of active cancer in the past 3 years except for squamous or basal cell carcinomas of the skin that have been medically managed by local excision
    • * Unstable dietary history as defined by major changes in diet during the previous month, where the subject has eliminated or significantly increased a major food group in the diet.
    • * Recent history of chronic excessive alcohol consumption defined as more than five 1.5-ounce servings of 80 proof distilled spirits, five 12-ounce servings of beer or five 5-ounce servings of wine per day; or \> 14 drinks/week.
    • * Any confirmed or suspected condition/state of immunosuppression or immunodeficiency (primary or acquired) including HIV infection, multiple sclerosis, and Graves' disease.
    • * Surgery of the GI tract, with the exception of cholecystectomy and appendectomy, in the past five years. Any major bowel resection at any time.
    • * Regular/frequent use of smoking or chewing tobacco, e-cigarettes, cigars or other nicotine-containing products
    • * Regular use of prescription opiate pain medication
IGNITE Firefighters' Health

Location Details

NCT06567561

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Locations

RECRUITING

United States, California

Stanford University

Palo Alto, California, United States, 94305