Thinking of joining a study?

Register your interest

Become a volunteer?

NCT06529744 | RECRUITING | Dementia

Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
Sponsor:

University Health Network, Toronto

Information provided by (Responsible Party):

Carmela Tartaglia

Brief Summary:

To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease, including Alzheimer's Disease (AD), Lewy Body Disease (LBD), Vascular Disease (VaD) and Frontotemporal lobar degeneration (FTLD).

Condition or disease

Dementia

Alzheimer Disease

Dementia with Lewy Bodies

Vascular Dementia

Frontotemporal Dementia

Mild Cognitive Impairment

Corticobasal Syndrome

Progressive Supranuclear Palsy

Parkinson Disease

Primary Progressive Aphasia

Detailed Description:

The goal of this study is to create a model to predict disease progression in patients with mild cognitive impairments and forms of dementia. To accomplish this, the current study will evaluate different tests including: brain imaging (MRI), body fluid samples (blood and cerebrospinal fluid), skin biopsy, cognitive ability, and behavioural questionnaires. The study team hopes that this information can be used to guide diagnosis and better predict disease progression in patients with mild cognitive impairment and and early dementia.

Study Type : OBSERVATIONAL
Estimated Enrollment : 500 participants
Official Title : Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
Actual Study Start Date : 2023-11-11
Estimated Primary Completion Date : 2026-11
Estimated Study Completion Date : 2027-11

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 40 Years to 95 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Referring diagnosis of MCI or early dementia
  • * Age 40-95
  • * Study partner who has some weekly contact with patient. Some of the neuropsychological assessment require collateral from close contacts to assess cognition and functioning. Since neurodegenerative diseases can be associated with reduced cognition, including reduced awareness of one's own impairments, participants will be assessed for their capacity to consent at all study visits.
  • * Must, in the opinion of the site investigator, be able to complete most study procedures.
Exclusion Criteria
  • * Participants who are not able to complete the majority of assessments in the opinion of the PI are excluded from the study. Exclusion criteria are evaluated at the site investigator's discretion; if the site investigator believes that the participant's symptoms are due to causes other than neurodegeneration, despite the presence of an exclusionary condition, the investigator may overrule the exclusion.
Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling

Location Details

NCT06529744

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

NOT YET RECRUITING

Canada, Ontario

Baycrest

North York, Ontario, Canada, M6a 2 picture 1

NOT YET RECRUITING

Canada, Ontario

Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada, M4N 3M5

RECRUITING

Canada, Ontario

Toronto Western Hospital, University Health Network

Toronto, Ontario, Canada, M5T 2S8

NOT YET RECRUITING

Canada, Ontario

Centre for Addiction and Mental Health

Toronto, Ontario, Canada, 6 h 1 1