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NCT06528314 | RECRUITING | NASH - Nonalcoholic Steatohepatitis

A Study Evaluating Efruxifermin in Subjects with Compensated Cirrhosis Due to NASH/MASH
Sponsor:

Akero Therapeutics, Inc

Brief Summary:

This is a multi-center evaluation of efruxifermin (EFX) in a randomized, double-blind, placebo-controlled study in subjects with compensated cirrhosis due to NASH/MASH.

Condition or disease

NASH - Nonalcoholic Steatohepatitis

MASH - Metabolic Dysfunction-Associated Steatohepatitis

Intervention/treatment

Efruxifermin

Placebo

Phase

PHASE3

Study Type : INTERVENTIONAL
Estimated Enrollment : 1150 participants
Masking : QUADRUPLE
Primary Purpose : TREATMENT
Official Title : A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Subjects with Compensated Cirrohosis Due to NASH/MASH
Actual Study Start Date : 2024-09-04
Estimated Primary Completion Date : 2029-09
Estimated Study Completion Date : 2029-10

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years to 80 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Cohort 1: Biopsy proven compensated cirrhosis (fibrosis stage 4) due to NASH/MASH
  • * Cohort 2: Biopsy proven or non-invasively diagnosed compensated cirrhosis (fibrosis stage 4) due to NASH/MASH
Exclusion Criteria
  • * Other causes of liver disease based on medical history and/or liver histology and/or central laboratory results
  • * Type 1 diabetes or unstable Type 2 diabetes
  • * Any current or prior history of decompensated liver disease
  • Other inclusion and exclusion criteria may apply
A Study Evaluating Efruxifermin in Subjects with Compensated Cirrhosis Due to NASH/MASH

Location Details

NCT06528314

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, alabama

Akero Clinical Study Site

Birmingham, alabama, United States, 35209

RECRUITING

United States, alabama

Akero Clinical Study Site

Dothan, alabama, United States, 36301

RECRUITING

United States, Arizona

Akero Clinical Study Site

Chandler, arizona, United States, 85224

RECRUITING

United States, Arizona

Akero Clinical Study Site

Flagstaff, arizona, United States, 86001

RECRUITING

United States, Arizona

Akero Clinical Study Site

Peoria, arizona, United States, 85381

RECRUITING

United States, Arizona

Akero Clinical Study Site

Tucson, arizona, United States, 85712

RECRUITING

United States, Arizona

Akero Clinical Study Site

Tucson, arizona, United States, 85715

RECRUITING

United States, Arkansas

Akero Clinical Study Site

Conway, arkansas, United States, 72032

RECRUITING

United States, Arkansas

Akero Clinical Study Site

Jonesboro, arkansas, United States, 72401

RECRUITING

United States, Arkansas

Akero Clinical Study Site

Little Rock, arkansas, United States, 72205

RECRUITING

United States, Arkansas

Akero Clinical Study Site

North Little Rock, arkansas, United States, 72117

RECRUITING

United States, California

Akero Clinical Study Site

Coronado, California, United States, 92118

RECRUITING

United States, California

Akero Clinical Study Site

Long Beach, California, United States, 90815

RECRUITING

United States, California

Akero Clinical Study Site

Pasadena, California, United States, 91105

RECRUITING

United States, Colorado

Akero Clinical Study Site

Englewood, Colorado, United States, 80113

RECRUITING

United States, Florida

Akero Clinical Study Site

Bradenton, florida, United States, 34208

RECRUITING

United States, Florida

Akero Clinical Study Site

Brandon, florida, United States, 33511

RECRUITING

United States, Florida

Akero Clinical Study Site

Fort Myers, florida, United States, 33912

RECRUITING

United States, Florida

Akero Clinical Study Site

Hialeah Gardens, florida, United States, 33016

RECRUITING

United States, Florida

Akero Clinical Study Site

Lakewood Ranch, florida, United States, 34211

RECRUITING

United States, Florida

Akero Clinical Study Site

Naples, florida, United States, 34102

RECRUITING

United States, Florida

Akero Clinical Study Site

Ocala, florida, United States, 34471

RECRUITING

United States, Florida

Akero Clinical Study Site

Orlando, florida, United States, 32806

RECRUITING

United States, Florida

Akero Clinical Study Site

Pembroke Pines, florida, United States, 33027

RECRUITING

United States, Florida

Akero Clinical Study Site

Sarasota, florida, United States, 34240

RECRUITING

United States, Florida

Akero Clinical Study Site

Venice, florida, United States, 34285

RECRUITING

United States, Florida

Akero Clinical Study Site

Viera, florida, United States, 32940

RECRUITING

United States, Georgia

Akero Clinical Study Site

Gainesville, Georgia, United States, 30501

RECRUITING

United States, Georgia

Akero Clinical Study Site

Marietta, Georgia, United States, 30060

RECRUITING

United States, Georgia

Akero Clinical Study Site

Snellville, Georgia, United States, 30078

RECRUITING

United States, Indiana

Akero Clinical Study Site

South Bend, Indiana, United States, 46635

RECRUITING

United States, Kansas

Akero Clinical Study Site

Topeka, Kansas, United States, 66606

RECRUITING

United States, Louisiana

Akero Clinical Study Site

Covington, Louisiana, United States, 70433

RECRUITING

United States, Louisiana

Akero Clinical Study Site

Houma, Louisiana, United States, 70363

RECRUITING

United States, Louisiana

Akero Clinical Study Site

Marrero, Louisiana, United States, 70072

RECRUITING

United States, Louisiana

Akero Clinical Study Site

Metairie, Louisiana, United States, 70006

RECRUITING

United States, Louisiana

Akero Clinical Study Site

Shreveport, Louisiana, United States, 71105

RECRUITING

United States, Maryland

Akero Clinical Study Site

Baltimore, Maryland, United States, 21202

RECRUITING

United States, Massachusetts

Akero Clinical Study Site

Dartmouth, Massachusetts, United States, 02747

RECRUITING

United States, road cancer

Akero Clinical Study Site

Clinton Township, road cancer, United States, 48038

RECRUITING

United States, Missouri

Akero Clinical Study Site

Columbia, Missouri, United States, 65201

RECRUITING

United States, Missouri

Akero Clinical Study Site

Kansas City, Missouri, United States, 64131

RECRUITING

United States, Nevada

Akero Clinical Study Site

vegas, Nevada, United States, 89106

RECRUITING

United States, New Jersey

Akero Clinical Study Site

Jackson, New Jersey, United States, 08527

RECRUITING

United States, New Jersey

Akero Clinical Study Site

Sparta, New Jersey, United States, 07871

RECRUITING

United States, New York

Akero Clinical Study Site

New York, New York, United States, 10029

RECRUITING

United States, North Carolina

Akero Clinical Study Site

Charlotte, North Carolina, United States, 28204

RECRUITING

United States, North Carolina

Akero Clinical Study Site

Charlotte, North Carolina, United States, 28207

RECRUITING

United States, North Carolina

Akero Clinical Study Site

Fayetteville, North Carolina, United States, 28304

RECRUITING

United States, North Carolina

Akero Clinical Study Site

Statesville, North Carolina, United States, 28625

RECRUITING

United States, Ohio

Akero Clinical Study Site

Springboro, Ohio, United States, 45066

RECRUITING

United States, Ohio

Akero Clinical Study Site

Westlake, Ohio, United States, 44145

RECRUITING

United States, Pennsylvania

Akero Clinical Study Site

Philadelphia, Pennsylvania, United States, 19107

RECRUITING

United States, South Carolina

Akero Clinical Study Site

Columbia, South Carolina, United States, 29204

RECRUITING

United States, South Carolina

Akero Clinical Study Site

Summerville, South Carolina, United States, 29485

RECRUITING

United States, Tennessee

Akero Clinical Study Site

Clarksville, Tennessee, United States, 37040

RECRUITING

United States, Tennessee

Akero Clinical Study Site

Hermitage, Tennessee, United States, 37076

RECRUITING

United States, Tennessee

Akero Clinical Study Site

Nashville, Tennessee, United States, 37211

RECRUITING

United States, Texas

Akero Clinical Study Site

Yellow, Texas, United States, 79106

RECRUITING

United States, Texas

Akero Clinical Study Site

Austin, Texas, United States, 78745

RECRUITING

United States, Texas

Akero Clinical Study Site

Austin, Texas, United States, 78757

RECRUITING

United States, Texas

Akero Clinical Study Site

Brownsville, Texas, United States, 78520

RECRUITING

United States, Texas

Akero Clinical Study Site

Corpus Christi, Texas, United States, 78404

RECRUITING

United States, Texas

Akero Clinical Study Site

dallas, Texas, United States, 75203

RECRUITING

United States, Texas

Akero Clinical Study Site

dallas, Texas, United States, 75234

RECRUITING

United States, Texas

Akero Clinical Study Site

dallas, Texas, United States, 75246

RECRUITING

United States, Texas

Akero Clinical Study Site

dallas, Texas, United States, 75390

RECRUITING

United States, Texas

Akero Clinical Study Site

Denison, Texas, United States, 75020

RECRUITING

United States, Texas

Akero Clinical Study Site

Edinburg, Texas, United States, 78539

RECRUITING

United States, Texas

Akero Clinical Study Site

Edinburg, Texas, United States, 78539

RECRUITING

United States, Texas

Akero Clinical Study Site

Fort Worth, Texas, United States, 76104

RECRUITING

United States, Texas

Akero Clinical Study Site

Garland, Texas, United States, 75044

RECRUITING

United States, Texas

Akero Clinical Study Site

Houston, Texas, United States, 77079

RECRUITING

United States, Texas

Akero Clinical Study Site

Saint Anthony, Texas, United States, 78222

RECRUITING

United States, Texas

Akero Clinical Study Site

Saint Anthony, Texas, United States, 78229

RECRUITING

United States, Texas

Akero Clinical Study Site

Saint Anthony, Texas, United States, 78229

RECRUITING

United States, Texas

Akero Clinical Study Site

Sugar Land, Texas, United States, 77478

RECRUITING

United States, Texas

Akero Clinical Study Site

Waco, Texas, United States, 76710

RECRUITING

United States, Texas

Akero Clinical Study Site

Webster, Texas, United States, 77598

RECRUITING

United States, Texas

Akero Clinical Study Site

Wichita Falls, Texas, United States, 76301

RECRUITING

United States, Virginia

Akero Clinical Study Site

Norfolk, Virginia, United States, 23502

RECRUITING

United States, Virginia

Akero Clinical Study Site

Richmond, Virginia, United States, 23236

RECRUITING

United States, Virginia

Akero Clinical Study Site

Richmond, Virginia, United States, 23249

RECRUITING

United States, Virginia

Akero Clinical Study Site

Roanoke, Virginia, United States, 24014

RECRUITING

Australia, New South Wales

Akero Clinical Study Site

Westmead, New South Wales, Australia, 2145

RECRUITING

Australia, South Australia

Akero Clinical Study Site

Adelaide, South Australia, Australia, 5000

RECRUITING

Australia, Victoria

Akero Clinical Study Site

Box Hill, Victoria, Australia, 3128

RECRUITING

Australia, Victoria

Akero Clinical Study Site

Clayton, Victoria, Australia, 3168

RECRUITING

Australia, Victoria

Akero Clinical Study Site

Epping, Victoria, Australia, 3076

RECRUITING

Australia, Victoria

Akero Clinical Study Site

Melbourne, Victoria, Australia, 3004

RECRUITING

Canada, Alberta

Akero Clinical Study Site

Edmonton, Alberta, Canada, T6G 2X8

RECRUITING

Canada, Ontario

Akero Clinical Study Site

Toronto, Ontario, Canada, M6H 3M1

RECRUITING

Canada, Ontario

Akero Clinical Study Site

Vaughan, Ontario, Canada, L4L 4Y7

RECRUITING

France, Hauts-de-Seine

Akero Clinical Study Site

Clichy, Hauts-de-Seine, France, 92118

RECRUITING

France, Ile-de-France

Akero Clinical Study Site

Paris, Ile-de-France, France, 75013

RECRUITING

India, Gujarat

Akero Clinical Study Site

Surat, Gujarat, India, 395009

RECRUITING

India, Maharashtra

Akero Clinical Study Site

Nagpur, Maharashtra, India, 440010

RECRUITING

India, Maharashtra

Akero Clinical Study Site

Pune, Maharashtra, India, 412201

RECRUITING

India, Rajasthan

Akero Clinical Study Site

Jaipur, Rajasthan, India, 302001

RECRUITING

India, Telangana

Akero Clinical Study Site

Hyderabad, Telangana, India, 500 004

RECRUITING

India, Uttar Pradesh

Akero Clinical Study Site

Varanasi, Uttar Pradesh, India, 221005

RECRUITING

India, West Bengal

Akero Clinical Study Site

Kolkata, West Bengal, India, 700020

RECRUITING

Puerto Rico,

Akero Clinical Study Site

Manatee, Puerto Rico, 00674

RECRUITING

Puerto Rico,

Akero Clinical Study Site

Saint John, Puerto Rico, 00927

RECRUITING

Spain, Cantabria

Akero Clinical Study Site

Santander, Cantabria, Spain, 39008