Thinking of joining a study?

Register your interest

Become a volunteer?

NCT06489626 | RECRUITING | Arthritis Knee

The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty
Sponsor:

F. Johannes Plate

Information provided by (Responsible Party):

F. Johannes Plate

Brief Summary:

Pain control and early range of motion following total knee arthroplasty are essential for patient satisfaction. Intraoperative steroids (dexamethasone) have been shown to have a significant effect in controlling acute pain following total knee arthroplasty. This study aims to evaluate the effect of a post-operative steroid (methylprednisolone) taper in improving functional and patient-reported outcomes following total knee arthroplasty. A taper means taking a high dose of a medication followed by taking lower doses and each following day until the medication is stopped.

Condition or disease

Arthritis Knee

Knee Osteoarthritis

Pain, Postoperative

Intervention/treatment

Methylprednisolone 4 milligram Tab

Dexamethasone injection

Phase

PHASE4

Study Type : INTERVENTIONAL
Estimated Enrollment : 100 participants
Masking : SINGLE
Primary Purpose : TREATMENT
Official Title : The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty
Actual Study Start Date : 2024-10-01
Estimated Primary Completion Date : 2025-10-01
Estimated Study Completion Date : 2025-12-01

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Patients indicated for primary total knee arthroplasty.
  • * Access to computer or smartphone for completion of REDCap surveys
Exclusion Criteria
  • * Patients less than 18 years of age, patients unable to consent, known diabetic patients and those with an HgbA1c \>6.5 preoperatively, patients who are on chronic steroid treatments, patients with chronic pain on opioid management, patients with allergies to steroids, patients with a history of peptic ulcer disease, patients with a history of heart failure and patients with a history of renal and/or hepatic failure will be excluded. Those that are immunosuppressed as well as pregnant and/or lactating will also be excluded.
The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty

Location Details

NCT06489626

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Pennsylvania

UPMC East

Monroeville, Pennsylvania, United States, 15146

RECRUITING

United States, Pennsylvania

UPMC Shadyside Hospital

Pittsburgh, Pennsylvania, United States, 15232