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NCT06482957 | RECRUITING | Sarcoma

Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan
Sponsor:

Vanderbilt-Ingram Cancer Center

Information provided by (Responsible Party):

Debra Friedman

Brief Summary:

This study evaluates the impact that a sarcoma diagnosis and treatment have had on patients over time.

Condition or disease

Sarcoma

Intervention/treatment

Surveys

Blood Collection

Saliva Collection

Urine Collection

Stool Collection

Tissue collection

Physical Activity Monitoring

Detailed Description:

* To evaluate the incidence and prevalence and the impact of disease, treatment, sociodemographic and lifestyle contributors on adverse oncologic outcomes (lack of response, recurrence) and non- oncologic outcomes (physical and psychosocial function, financial toxicity, short and long-term organ toxicity) and mortality in the cohort. * To evaluate the role of drug metabolism and DNA repair genes via functional polymorphisms, known toxicity associated polymorphisms and genetically predicted gene expression levels, as well as polygenic risk scores, on treatment efficacy, cancer therapy-induced normal tissue toxicity and mortality. * To identify genomic drivers of sarcoma and to use this information to develop personalized liquid biopsy assays for monitoring treatment response, recurrence, and minimal residual disease (MRD) and mortality. * Evaluate family functioning, psychosocial wellbeing, and financial toxicity. OUTLINE: This is an observational study. Patients monitor physical activity, sedentary behavior, heart rate and sleep wearing a FitBit device, undergo blood urine, stool and/or saliva sample collection, complete surveys and have medical records reviewed throughout study.

Study Type : OBSERVATIONAL
Estimated Enrollment : 2100 participants
Official Title : CAUSAL: Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan
Actual Study Start Date : 2022-04-01
Estimated Primary Completion Date : 2028-04
Estimated Study Completion Date : 2029-04

Information not available for Arms and Intervention/treatment

Ages Eligible for Study:
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: 1
Criteria
Patients at any age with a history of sarcoma, with or without evidence of a persistent disease
  • • For pediatric patients
  • * Parent/primary caregiver of patient
  • * Sibling of patient aged 8 years or older
    • Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan

    Location Details

    NCT06482957

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    How to Participate

    Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

    Locations

    RECRUITING

    United States, Tennessee

    Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, United States, 37203