Wake Forest University Health Sciences
The purpose of this study is to understand why there is a greater risk of thrombosis in patients who have the JAK2 mutation as compared to those with CALR mutations.
Myeloproliferative Neoplasm
Blood Draw
This biospecimen study is designed to evaluate the expression levels of TLR 2 and TLR 4 on mononuclear cells in CALR mutation positive MPN participants and compare to JAK2 V617F mutation positive MPN patients and healthy controls. Patients who have MPN with the CALR mutation positive will be approached for interest in participating in this study. A research blood collection will occur at any time during the participant's cancer trajectory after enrollment, during a standard of care blood draw. The participant's demographics, MPN subtype, CALR mutation status, history of thrombosis/other medical history, and current, concomitant medications will be collected once. Clinical data will be collected, including results from the CBC with differential, complete metabolic panel (if available), and PT/PTT/INR (if available) drawn closest to the research blood collection. This study will initially open as a single center study at AHWFBCCC.
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 35 participants |
| Official Title : | Evaluation of the Pathobiology of CALR-mutated MPN Cells |
| Actual Study Start Date : | 2024-12 |
| Estimated Primary Completion Date : | 2026-02 |
| Estimated Study Completion Date : | 2026-02 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: | 1 |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Not yet recruiting
Atrium Health Levine Cancer
Charlotte, North Carolina, United States, 28204
Not yet recruiting
Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem, North Carolina, United States, 27157