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NCT06441474 | NOT YET RECRUITING | Breast Cancer Female

Understanding and Addressing Rejection of Personalized Breast Cancer Risk Information in Women
Sponsor:

University of Colorado, Denver

Brief Summary:

The Understanding and Addressing Rejection of Personalized Cancer Risk Information study is a longitudinal observational study conducted to understand the nature of phenomenon of personalized cancer risk rejection in the context of mammography screening.

Condition or disease

Breast Cancer Female

Detailed Description:

The Understanding and Addressing Rejection of Personalized Cancer Risk Information study seeks to understand the nature of the phenomenon of personalized cancer risk rejection in the context of mammography screening by 1) identifying demographic and psychological factors associated with risk rejection and 2) identify how risk rejection influences risk-concordant mammography seeking behavior. The study will test a priori theory-derived hypotheses about the precursors of risk rejection and the influence of rejection on real-life screening decision making. The Breast Cancer Risk Assessment Tool (BCRAT) will be used to asses participant's breast cancer risk. This model is designed to estimate breast cancer risk in women 35-84, and uses the following predictors: 1) age, 2) age at first menstrual period, 3) age at first live birth, 4) first-degree relatives with breast cancer, 5) previous breast biopsy with atypical hyperplasia, and 6) race/ethnicity Participants will be required to complete the baseline survey in which they receive their Gail model risk estimate and respond to that risk estimate. They will then complete a 12-month follow-up survey.

Study Type : OBSERVATIONAL
Estimated Enrollment : 750 participants
Official Title : Understanding and Addressing Rejection of Personalized Cancer Risk Information
Actual Study Start Date : 2024-12
Estimated Primary Completion Date : 2025-12
Estimated Study Completion Date : 2026-12

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 39 Years to 49 Years
Sexes Eligible for Study: FEMALE
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1. Female sex
  • 2. Age 39-49 (i.e., people who are eligible for routine breast cancer screening and for whom guidelines recommend an informed, risk-based decision)
  • 3. English literacy
Exclusion Criteria
  • 1. Prior diagnosis of
  • 1. breast cancer
  • 2. Ductal carcinoma in situ (DCIS)
  • 3. Lobular carcinoma in situ (LCIS)
  • 4. Known BRCA1/2 gene mutation
  • 5. Cowan syndrome
  • 6. Li-Fraumeni syndrome
  • 7. Having received previous chest radiation for treatment of Hodgkin's lymphoma.
Understanding and Addressing Rejection of Personalized Breast Cancer Risk Information in Women

Location Details

NCT06441474

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Not yet recruiting

United States, Colorado

University of Colorado Denver

Aurora, Colorado, United States, 80045

Not yet recruiting

United States, Missouri

Washington University in St. Louis

St. Louis, Missouri, United States, 63130