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NCT06425926 | RECRUITING | Melanoma Stage IV

Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors
Sponsor:

Georgiamune Inc

Brief Summary:

GIM-531 is a first-in-class, orally bioavailable small molecule that is being developed for the treatment of advanced solid tumors as a single agent and rescue therapy. GIM-531 exhibits its primary effect through selective inhibition of regulatory T-cells (Tregs).

Condition or disease

Melanoma Stage IV

Solid Tumor

Intervention/treatment

GIM-531

Anti-PD-1 monoclonal antibody

Phase

PHASE1

PHASE2

Detailed Description:

GIM531-CT01 is a Phase 1/2 open label, first-in-human, multicenter study. The Phase 1 portion will include a dose escalation with GIM-531 administered as a single agent. Additionally, there will be a dose expansion portion at the safety-cleared dose levels with participants allocated 1:1 within the proposed therapeutic range to accrue additional data for determining the safety profile, pharmacokinetics (PK) profile, pharmacodynamic (PD) effects and early anti-tumor activity of GIM-531. In Phase 2, GIM-531will be administered to participants with advanced/metastatic cutaneous melanoma who have progressed following treatment with an anti-PD-1 therapy.

Study Type : INTERVENTIONAL
Estimated Enrollment : 117 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : A Phase 1/2, Open-label, Multi-center Study of the Safety, Tolerability, and Efficacy of GIM-531 as a Single Agent and in Combination With Anti-PD-1 in Advanced Solid Tumors
Actual Study Start Date : 2024-05-09
Estimated Primary Completion Date : 2025-12
Estimated Study Completion Date : 2026-11

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Key Inclusion Criteria
  • * Written informed consent
  • * Cytologically or histologically confirmed locally advanced or metastatic solid tumor that has progressed on standard therapy or for which no standard therapy exist; or be intolerant of standard therapy
  • * Have not received an experimental drug within 4 weeks or 5 half-lives (whichever is shorter) of study drug treatment or already be enrolled in a clinical study
  • * ECOG performance status 0-1
  • * Laboratory and ECG assessments within 28 days of enrollment including acceptable cardiac, renal, and hepatic functions
  • * Agree to baseline core needle biopsy or archival (within 12 months of screening) tumor submission; Note: Participants whose only site(s) of disease are in areas considered moderate or high risk for biopsy complications may be enrolled without a fresh biopsy upon Sponsor approval.
  • * Non pregnant participants; female participants of child bearing potential with non-sterile partners agree to use an effective form of contraception from the time of first dose of study drug (or 14 days prior to first dose for oral contraception) until 7 months after the last dose of study drug. Effective forms of contraception include hormonal (injection or oral), double barrier method, or intrauterine device. Non-sterile male participants with sexual partners of childbearing potential agree to use a barrier contraception method and agree to not donate sperm from the time of first dose of study drug until 4 months after the last dose of study drug.
  • * Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1
  • Phase 1 Expansion Cohorts Specific Inclusion Criteria (in addition to above inclusion criteria)
    • * NSCLC: Participants must have locally advanced/unresectable or metastatic NSCLC. Participants must have received ≤2 prior lines of therapy in the advanced/metastatic setting.
    • * TNBC: Participants must have locally advanced unresectable, recurrent, or metastatic TNBC. Participants must have received ≤2 prior lines of therapy in the advanced/metastatic setting. TNBC participants with germline BRCA1/2 mutations must have received ≤3 prior lines of therapy in the advanced/metastatic setting.
    • * Ovarian Cancer: Participants must have locally advanced unresectable, recurrent, or metastatic ovarian cancer. Participants must have received ≤2 prior lines of therapy in the advanced/metastatic setting with or without maintenance treatment.
    • * Tumors with AKT3 mutation/amplification: Participants must have a locally advanced unresectable, recurrent, or metastatic solid malignancy. Participants with known AKT3 mutation/amplification based on next generation sequencing (NGS) performed per local standard of care.
    • Phase 2 Specific Inclusion Criteria (in addition to above inclusion criteria)
      • * Have confirmed unresectable Stage III or metastatic Stage IV cutaneous melanoma that has radiographically progressed (as confirmed by imaging assessed by the Investigator) on an approved first-line single-agent or combination anti-PD-1 therapy
      • * Receiving anti-PD-1 therapy as their first line of treatment at the time of enrollment and amenable to continuing anti-PD-1 therapy during the study
      • Key Exclusion Criteria
        • * Ongoing \>Grade 1 toxicity from prior therapy according to Common Terminology Criteria for Adverse Events v5.0 (Note: Grade 2 alopecia and Grade 2 sensory neuropathy are not exclusionary)
        • * Has melanoma with documented BRAF mutation (Phase 2 only)
        • * Has known leptomeningeal disease, spinal cord compression, or brain metastases, except participants with the following
          • * Brain metastases that have been treated and are clinically stable for at least 4 weeks prior to the first administration of study drug; Note: Participants receiving steroids for brain metastases must be either off steroids or on a stable, or decreasing dose, of \<10 mg daily of prednisone (or equivalent) in order to be eligible for enrollment; and
          • * No ongoing neurological symptoms related to the anatomic location of the brain metastases.
          • Note: Neurological symptoms that are considered sequelae to treatment for brain metastases are allowed.
          • * Has known structural cardiac disease
          • * Has known serious arrythmia, serious dysrhythmia, history of long QT syndrome, or clinically relevant cardiac conduction abnormalities
          • * Has an active autoimmune disease that has required systemic treatment in the past 2 years (ie, with use of disease modifying agents, corticosteroids, or immunosuppressive drugs). Replacement therapy (eg, thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed.
          • * At time of screening, is receiving systemic steroid therapy (greater than or equal to 10 mg/day of prednisone or equivalent) or is taking any immunosuppressive therapy; Note: Use of topical, inhaled, nasal, or ophthalmic steroids is allowed.
          • * Has active and clinically significant bacterial, fungal, or viral infection, including known hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV)
          • * Has a history of, or currently has, an acquired or primary (congenital) immunodeficiency;
          • * Has had prior anti-cancer treatment with chemotherapeutic agents or immune modulating agents within \<4 weeks or 5 half-lives, whichever is shorter, prior to the first dose of study drug.
          • * Has received a live vaccine within 30 days of first dose of study drug;
          • * Has had or has planned major surgery within 2 weeks of the first dose of study drug;
          • * Inability to swallow an oral dose of a medication (eg, oral capsules)
          • * Is taking medications that are considered strong inducers or inhibitors of CYP2C8 or CYP3A4/5, P-glycoprotein (P-gp), breast cancer resistant protein (BCRP), or sensitive substrates of P-gp and BCRP (Appendix C) that cannot be discontinued at least 1 week prior to first dose of study drug and for the duration of the study.
          • * Is taking drugs that modify gastric pH, such as proton-pump inhibitors (PPIs) or H2 blockers. Antacids such as calcium carbonate or aluminum hydroxide-based products are permitted.
Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors

Location Details

NCT06425926

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, Arizona

Honor Health Research Institute

Scottsdale, Arizona, United States, 85258

RECRUITING

United States, California

Comprehensive Blood and Cancer Center

Bakersfield, California, United States, 93309

RECRUITING

United States, California

Providence Medical Foundation

Fullerton, California, United States, 92835

RECRUITING

United States, California

The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate

Los Angeles, California, United States, 90025

RECRUITING

United States, California

UCSF Helen Diller Family Comprehensive Cancer Center

San Francisco, California, United States, 94143

RECRUITING

United States, Massachusetts

Massachusetts General Hospital

Boston, Massachusetts, United States, 02114

RECRUITING

United States, Montana

Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana

Billings, Montana, United States, 59102

RECRUITING

United States, Ohio

University of Cincinnati Cancer Center

Cincinnati, Ohio, United States, 45267

RECRUITING

United States, Tennessee

Tennessee Oncology, PLLC

Nashville, Tennessee, United States, 37203

RECRUITING

United States, Virginia

Virginia Commonwealth University

Richmond, Virginia, United States, 23219