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NCT06414460 | NOT YET RECRUITING | Locally Advanced/Metastatic Solid Tumors

Study of ISM3412 in Participants With Locally Advanced/Metastatic Solid Tumors
Sponsor:

InSilico Medicine Hong Kong Limited

Brief Summary:

The study has consists of two parts, a dose escalation part (Part 1) and a dose selection optimization part (Part 2). The primary objectives of this study are to evaluate the safety and tolerability of ISM3412 in participants with locally advanced/metastatic solid tumors, and to determine the RP2D of ISM3412.

Condition or disease

Locally Advanced/Metastatic Solid Tumors

Intervention/treatment

ISM3412

Phase

PHASE1

Study Type : INTERVENTIONAL
Estimated Enrollment : 80 participants
Masking : NONE
Primary Purpose : TREATMENT
Official Title : A Phase 1, Open-Label, Multicenter, First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics/Pharmacodynamics, and Preliminary Efficacy of ISM3412 in Participants With Locally Advanced/Metastatic Solid Tumors
Actual Study Start Date : 2025-03-01
Estimated Primary Completion Date : 2028-03-31
Estimated Study Completion Date : 2029-03-31

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • 1. Male or female participants with age ≥18 years at the time of signing the informed consent.
  • 2. Histologically confirmed unresectable locally advanced or metastatic solid tumors with confirmed homozygous MTAP deletion, who have disease progression after standard therapy, intolerable to standard therapy, or for whom no standard therapy exists.
  • 3. Have measurable or evaluable lesions in Part 1 and at least one measurable target lesion in Part 2 as defined by Response Evaluation Criteria in Solid Tumors (RECIST) criteria.
  • 4. Participants must provide a documentary evidence of homozygous MTAP deletion; or provide archival formalin-fixed paraffin-embedded (FFPE) tumor tissue blocks or at least 15 FFPE tumor tissue slides, or perform tumor tissue biopsies for a confirmatory genetic test indicating homozygous MTAP deletion.
  • 5. ECOG PS (Eastern Cooperative Oncology Group Performance Status) ≤1.
  • 6. Life expectancy of ≥12 weeks as judged by the investigator.
  • 7. Adequate organ function as determined by medical assessment.
  • 8. Capable of providing signed ICF and complying with the requirements and restrictions listed in the ICF and in this study protocol.
Exclusion Criteria
  • 1. Prior treated with other MAT2A inhibitors and/or PRMT inhibitors.
  • 2. Participation in other therapeutic clinical studies within 28 days or 5 half-lives (whichever is shorter) prior to first dose of study treatment.
  • 3. Anti-tumor therapy (chemotherapy, immunotherapy, hormonal therapy, targeted therapy, biologic therapy, or other anti-tumor therapy, except for hormones for hypothyroidism or estrogen replacement therapy, anti-estrogen analogues, agonists required to suppress serum testosterone levels) within 28 days or 5 half-lives, whichever is shorter prior to first dose of study treatment.
  • 4. Toxicities of prior therapy have not resolved to Grade ≤1 or to baseline (as evaluated by NCI CTCAE version 5.0)
  • 5. History of another primary tumor that has been diagnosed or required therapy within the past 3 years.
  • 6. Previous history of, or presence of Gilbert's syndrome.
  • 7. Previous history of myelodysplastic syndrome.
  • 8. Prior solid organ or hematopoietic stem cell transplant.
  • 9. Known active central nervous system (CNS) primary tumor or untreated CNS metastases.
  • 10. Have serious cardiovascular or cerebrovascular disease as per protocol.
  • 11. Presence of uncontrolled systemic infection as per protocol.
  • 12. Unwillingness or unable to comply with the requirements of oral drug administration, or presence of a gastro-intestinal condition.
  • Other protocol inclusion and exclusion criteria may apply.
Study of ISM3412 in Participants With Locally Advanced/Metastatic Solid Tumors

Location Details

NCT06414460

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How to Participate

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