University of Colorado, Denver
A study to identify patients with Rheumatoid Arthritis - Associated Interstitial Lung Disease (RA-ILD) that are at the highest risk for progression. The goal of the investigators is to recruit a group of patients with RA-ILD and collect information to help us understand more about disease progression. The investigators will do this using a combination of clinical, radiologic, and biologic features.
Rheumatoid Arthritis
Interstitial Lung Disease
Research Testing Performed (Laboratory)
Information Collected as Standard of Care
Research Testing Performed
The central hypothesis is that novel quantitative imaging and specific blood markers will be associated with progressive RA-ILD. The hypothesis will be tested through collection and analysis of peripheral blood, in addition to the analysis of HRCT (high-resolution computed tomography) scans performed as standard of care (clinical) on research subjects. Procedures performed: Baseline Year 0: Blood sample, buccal (cheek) swab, questionnaires and if performed clinically - Pulmonary Function tests, 6 Minute Walk Test, and HRCT scan of lungs Every 4 months (at clinic visit): Blood sample, questionnaires Year 1 and Year 2 Follow-ups: Blood sample, buccal (cheek) swab, questionnaires and if performed clinically - Pulmonary Function tests, 6 Minute Walk Test, and HRCT scan of lungs
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 450 participants |
| Official Title : | Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease (MOUNTAIN) |
| Actual Study Start Date : | 2024-01-22 |
| Estimated Primary Completion Date : | 2029-01 |
| Estimated Study Completion Date : | 2034-01 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years to 90 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
University of California San Francisco
San Francisco, California, United States, 94143
RECRUITING
University of Colorado Denver
Aurora, Colorado, United States, 80045
RECRUITING
University of Kansas
Kansas City, Kansas, United States, 66103
RECRUITING
University of Michigan
Ann Arbor, Michigan, United States, 48109