Southeast University, China
Lin GL IU
Monitoring airway pressure is essential for patients with mechanical ventilation. However, static airway pressure does not reflect alveolar pressure at all. Airway pressure is supposed to completely interrupt the communication between proximal airway opening and the distal alveolar and/or small airway structures. In this condition, some alveoli may still be inflated but do not communicate with proximal airways and auto-PEEP will give a biased estimated of mean alveolar pressure. To be note, distinguishing the airway closure and alveolar collapse can be challenging at times. The quasi-static PV curve is a useful bedside tool to set mechanical ventilation, which may help us to identify the airway closure and alveolar collapse. Meanwhile, the quasi-static PV curve can only reflects a global behaviour of the lung, while EIT may be a useful tool to assess the regional information on airway closure and alveolar collapse.
Mechanical Ventilation Pressure High
Critical Illness
pressure-volume curve with a low-flow insufflation of 5 L/min
Not Applicable
| Study Type : | Interventional |
| Estimated Enrollment : | 60 participants |
| Masking : | None (Open Label) |
| Primary Purpose : | Diagnostic |
| Official Title : | Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients |
| Actual Study Start Date : | May 30, 2024 |
| Estimated Primary Completion Date : | August 30, 2024 |
| Estimated Study Completion Date : | August 30, 2024 |
| Arm | Intervention/treatment |
|---|---|
|
Experimental: P-V curve group Enrolled patients will receive a PV curve with a low-flow insufflation of 5 L/min starting from 0 cmH2O to a maximal airway pressure corresponding to the plateau pressure. |
Other: pressure-volume curve with a low-flow insufflation of 5 L/min |
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Not yet recruiting
Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University
Nanjing, Jiangsu, China, 210000