City of Hope Medical Center
This study aims to prospective validate an exosome-based miRNA signature for noninvasive and early detection of pancreatic ductal adenocarcinoma.
Pancreatic Cancer
Pancreatic Carcinoma
Pancreatic Adenocarcinoma
Pancreatic Ductal Adenocarcinoma
Pancreatic Neoplasms
Pancreatic Cancer Stage I
Pancreatic Cancer Stage
Pancreatic Cancer Resectable
Pancreatic Cancer Stage 0
Pancreatic Cancer Stage II
Pancreatic Cancer Stage III
Pancreatic Cancer, Adult
Pancreatic Cancer Non-resectable
PANcreatic cancer Exosome Early detectiON (PANXEON)
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer. It often goes undetected until it is at an advanced stage, making it challenging to treat. Currently, only a small percentage of patients are diagnosed early enough for effective treatment. While a blood marker exists, called serum carbohydrate antigen 19-9 (CA19-9), it is used primarily to track the disease and it is unreliable for early detection. To address this problem, the researchers have developed a new method to analyze circulating vesicles (called exosomes), which contain specific genetic material called microRNAs (miRNAs). In a previous study, by analyzing both the miRNAs that circulate freely in serum and the miRNAs that are inside the exosomes, the researchers have already identified a combination of 13 miRNAs that could accurately detect early-stage PDAC. In this study, the researchers will test this method in a larger international cohort study. This study aims to confirm the effectiveness of this approach in accurately identifying PDAC at its earliest stages.
| Study Type : | OBSERVATIONAL |
| Estimated Enrollment : | 2000 participants |
| Official Title : | Early Detection of Pancreatic Cancer: Prospective Study |
| Actual Study Start Date : | 2023-03-15 |
| Estimated Primary Completion Date : | 2025-11-21 |
| Estimated Study Completion Date : | 2025-11-21 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 18 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: | 1 |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
Translational Genomics Research Institute
Phoenix, Arizona, United States, 85004
RECRUITING
Honorhealth
Scottsdale, Arizona, United States, 85258
RECRUITING
City of Hope Medical Center
Monrovia, California, United States, 91016
RECRUITING
Hoag Center
Newport Beach, California, United States, 92663
RECRUITING
OSF Healthcare
Peoria, Illinois, United States, 61637
RECRUITING
Ochsner Medical Center
Jefferson, Louisiana, United States, 70121
RECRUITING
Atlantic Health System
Morristown, New Jersey, United States, 07960
RECRUITING
Piedmont Medical Center
Rock Hill, South Carolina, United States, 29732
RECRUITING
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
RECRUITING
Nagoya University
Nagoya, Japan,
RECRUITING
Asan Medical Center
Seoul, Korea, Republic of,