Thinking of joining a study?

Register your interest

Become a volunteer?

NCT06384924 | RECRUITING | Skin Cancer

Raman Spectroscopy and Skin Cancer
Sponsor:

Renee Farrell

Information provided by (Responsible Party):

Renee Farrell

Brief Summary:

The goal of this observational study is to find out if Raman Spectroscopy, a type of imaging, can be used to determine the size of skin cancer tumors. The main question it aims to answer is: -Can Raman Spectroscopy help figure out how far a tumor spreads? This study will take measurements using laser light from an experimental, handheld probe by lightly touching the skin.

Condition or disease

Skin Cancer

Basal Cell Carcinoma

Squamous Cell Carcinoma

Intervention/treatment

Raman Spectroscopy handheld probe (EmVision, FL, USA)

Raman Spectroscopy laser source (Hubner Photonics Inc, CA, USA)

Detailed Description:

Radiation therapy is an alternative to surgery for localized tumors with excellent tumor control and cosmetic outcome. Raman Spectroscopy has potential to be a useful non-invasive, non-destructive, real-time, in-vivo tool for differentiation of cancerous vs. non-cancerous tissues. With this knowledge and future studies, this will ultimately guide skin brachytherapy more accurately and avoid unnecessary radiation to cosmetically and functionally important tissues including eyelid, nose, lips or skin folds. The purpose of this study is to determine the feasibility of Raman Spectroscopy to identify microscopic infiltration extent of skin cancer beyond grossly visible tumor, using artificial intelligence methods of supervised and un-supervised machine learning algorithms, including pattern recognition, convolutional neural networks, k-means clustering and principal component analysis.

Study Type : OBSERVATIONAL
Estimated Enrollment : 20 participants
Official Title : Pilot Study of Raman Spectroscopic Imaging for Skin Cancer
Actual Study Start Date : 2025-02-13
Estimated Primary Completion Date : 2027-02-13
Estimated Study Completion Date : 2027-02-13

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Histologically confirmed skin cancer (either basal cell carcinoma or squamous cell carcinoma)
  • * Participants must plan to receive brachytherapy treatment for the skin cancer at the study site.
  • * Ability to provide consent to the study.
Exclusion Criteria
  • * Patient belongs to a vulnerable population (Minors (under 18 years old), Adults unable to consent, prisoners).
  • * Lesions on the eyelid or in close proximity to the eye
  • * Pregnant women, or women of childbearing age who refuse pregnancy testing.
  • * Patient has pacemaker.
Raman Spectroscopy and Skin Cancer

Location Details

NCT06384924

Please Choose a site

How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

RECRUITING

United States, New York

Stony Brook Hospital

Stony Brook, New York, United States, 11794