The Methodist Hospital Research Institute
Jason S. Ahuero
The purpose of this study is to compare two different antibiotic regimens and techniques during total ankle arthroplasty (TAA). Primary Objective: Comparable levels of vancomycin will be found in bone, soft tissue, and systemic samples between patient groups. Secondary Objective: Compare 30 day and 90 day post-operative complication rates (infection) between the control (standard IV administration of vancomycin) vs the interventional group (intraosseous administration of vancomycin). The investigators hypothesize that there will be no difference in complication (infection) rates between groups.
Infections
Ankle Arthritis
Intraosseous Vancomycin Injection
Intravenous Vancomycin
PHASE4
Study Type : | INTERVENTIONAL |
Estimated Enrollment : | 40 participants |
Masking : | DOUBLE |
Masking Description : | single blind patient is blinded. Surgeon is not blinded. Lab technician measuring tissue concentrations are blinded. Research coordinator is not blinded. |
Primary Purpose : | TREATMENT |
Official Title : | Intraosseous vs. Intravenous Vancomycin Administration in Total Ankle Arthroplasty |
Actual Study Start Date : | 2023-12-13 |
Estimated Primary Completion Date : | 2027-04 |
Estimated Study Completion Date : | 2027-12 |
Information not available for Arms and Intervention/treatment
Ages Eligible for Study: | 18 Years |
Sexes Eligible for Study: | ALL |
Accepts Healthy Volunteers: |
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RECRUITING
Houston Methodist Hospital
Houston, Texas, United States, 77030