Maastricht University Medical Center
A body of animal studies as well as observational studies in humans demonstrated that butyrate is one SCFA that has pronounced positive effects on body weight control, inflammation, and insulin resistance. Even though the SCFA hexanoate is less researched, it has been shown to be involved in anti-inflammatory processes. Of note, acute human studies showed that fibre-induced metabolic improvements are linked to higher SCFA levels in the systemic circulation. It has been shown that a butyrate/hexanoate-enriched triglyceride oil enhanced systemic butyrate and hexanoate concentrations for a prolonged time. Yet, it remains to be determined whether a chronic increase in circulating butyrate and hexanoate concentrations translate into long-term benefits. In this study it is hypothesized that a chronic increase of butyrate/hexanoate in the circulation may improve host metabolism and metabolic health by improving adipose tissue function, reducing systemic lipid overflow and inflammation thereby increasing peripheral insulin sensitivity in individual with overweight/obesity and prediabetes.
Type 2 Diabetes
PreDiabetes
Obesity
butyrate/hexanoate-enriched triglycerides
Not Applicable
Study Type : | Interventional |
Estimated Enrollment : | 48 participants |
Masking : | Double |
Primary Purpose : | Basic Science |
Official Title : | Prevention of Diabetes With a Novel Butyrate-enriched Triglyceride |
Actual Study Start Date : | July 1, 2024 |
Estimated Primary Completion Date : | September 1, 2027 |
Estimated Study Completion Date : | September 1, 2027 |
Arm | Intervention/treatment |
---|---|
Experimental: butyrate/hexanoate-enriched triglycerides Oil containing butyrate and hexanoate-enriched triglycerides |
Dietary Supplement: butyrate/hexanoate-enriched triglycerides |
Placebo Comparator: placebo Oil devoid of butyrate and hexanoate but with similar composition as the intervention oil |
Dietary Supplement: butyrate/hexanoate-enriched triglycerides |
Ages Eligible for Study: | 20 Years to 70 Years |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Accepts Healthy Volunteers |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.