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NCT06380257 | Not yet recruiting | Anorexia Nervosa

Anorexia Nervosa and Brain in Adolescence
Sponsor:

Kuopio University Hospital

Information provided by (Responsible Party):

Virve Kekkonen

Brief Summary:

Aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in adolescence.

Condition or disease

Anorexia Nervosa

Intervention/treatment

Observational study methods

Detailed Description:

Anorexia nervosa is severe mental health problem with increased incidence rates in adolescence. Etiology of anorexia nervosa is still mostly unkonwn. Adolescence is also critical period of brain development. Aims of this follow-up study are to investigate effects of anorexia nervosa on brain structure and functions in both acute and remission state of anorexia nervosa in adolescence. Study group are young anorexia nervosa patients, and control group are healthy same-aged students. Research methods include non-invasive brain imaging methods such as Transcranial Magnetic Stimulation (TMS), and Magnetic Resonance Imaging (MRI). Other research methods are assessment of body composition, laboratory tests, self-rated questionnaires and psychiatric interview.

Study Type : Observational
Estimated Enrollment : 50 participants
Official Title : Anorexia Nervosa and Brain in Adolescence
Actual Study Start Date : September 2024
Estimated Primary Completion Date : August 2030
Estimated Study Completion Date : December 2030

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 16 Years to 19 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: Accepts Healthy Volunteers
Criteria
Inclusion Criteria
  • Study group: 1) age 16-19 years, 2) BMI below 17.5, 3) diagnosis: anorexia nervosa or atypical anorexia nervosa 4) diagnosed within last two years. Inclusion criteria.
  • Control group : 1) age 16-19 years, 2) BMI over 19.0, 3) No lifetime obesity (BMI over 30) nor eating disorder.
Exclusion Criteria
  • 1) glucose metabolism disorder or any chronic medical disorder, or medicine with possible effects on neurotransmitters, 2) previous mental health problem (excluded anorexia nervosa or atypical anorexia nervosa in study group), 3) smoking, nicotine products, alcohol or any other substance abuse or dependence, 4) contraindication for used brain imaging method.
Anorexia Nervosa and Brain in Adolescence

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Anorexia Nervosa and Brain in Adolescence

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