JHSPH Center for Clinical Trials
Stephan Ehrhardt
This is a multi-center randomized, sham-controlled clinical trial to determine the effectiveness of an air cleaner intervention aimed at improving indoor air quality on reducing COPD exacerbation risk and improving quality of life, functional status, rescue medication use.
Chronic Obstructive Pulmonary Disease (COPD)
Air cleaner
Sham air cleaner
Phase 3
The Multi-Center Clean Air Randomized Controlled Trial in COPD (Clean Air) is a multi-center, prospective, randomized, double-blind, sham-controlled trial that will enroll 770 former smokers with COPD over a 4-year period and follow participants at regular intervals for one year. The primary endpoint is respiratory specific quality of life. Secondary endpoints include rate of acute exacerbations, rescue medication use, quality of life, and cost-effectiveness.
Study Type : | Interventional |
Estimated Enrollment : | 770 participants |
Masking : | Quadruple |
Primary Purpose : | Prevention |
Official Title : | Multi-Center Clean Air Randomized Controlled Trial in COPD |
Actual Study Start Date : | September 2024 |
Estimated Primary Completion Date : | September 2027 |
Estimated Study Completion Date : | September 2028 |
Arm | Intervention/treatment |
---|---|
Experimental: Active air cleaner The active arm will receive two active air cleaners with high efficiency particulate air (HEPA) filters which remove particulate matter (PM), as well as activated carbon filters to remove Nitrogen Dioxide (NO2) and other trace gases. |
Device: Air cleaner |
Sham Comparator: Sham air cleaner The sham control treatment arm will receive two sham air cleaners that have the internal HEPA and carbon filters removed, but which will run normally, including similar noise, airflow, and overall appearance compared to active air cleaners, thus blinding participants to filter status. |
Device: Sham air cleaner |
Ages Eligible for Study: | 40 Years |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
Not yet recruiting
Johns Hopkins
Baltimore, Maryland, United States, 21224