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NCT06352086 | NOT YET RECRUITING | Vision Loss Partial

Understanding Visual Processing After Occipital Stroke

University of Rochester

Information provided by (Responsible Party):

Krystel Huxlin

Brief Summary:

The purpose of this study is to investigate how visual orientation discrimination and metacognition (i.e., perceptual confidence) are affected by occipital stroke that causes hemianopia and quadrantanopia in adults. This research will provide insight as to how the residual visual system, which not directly damaged by the occipital stroke, processes orientation (assayed in terms of orientation discrimination) and metacognition (by measuring perceptual confidence for orientation discrimination). These measures will be used to refine computational models that attempt to explain how the brain copes with loss of primary visual cortex (V1) as a result of stroke. This knowledge is essential to devise more effective visual rehabilitation therapies for patients suffering from occipital strokes.

Condition or disease

Vision Loss Partial

Vision; Loss, Both Eyes

Hemianopia, Homonymous



Stroke, Ischemic

Stroke - Occipital Infarction

Cortical Blindness

Occipital Lobe Infarct

Peripheral Visual Field Defect of Both Eyes

Estimated Enrollment : 20 participants
Official Title : Understanding Visual Processing After Occipital Stroke
Actual Study Start Date : 2024-09
Estimated Primary Completion Date : 2028-09
Estimated Study Completion Date : 2029-09

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 21 Years to 75 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Inclusion Criteria
  • * Residents of the United States or Canada
  • * MRI and/or CT scans showing unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained 1-year or more prior to enrollment
  • * Reliable visual field defects in both eyes as measured by Humphrey, Macular Integrity Assessment (MAIA), Goldmann, and/or equivalent perimetry. This deficit must be large enough to enclose a 5-deg diameter visual stimulus.
  • * Ability to fixate on visual targets reliably for 1000ms (as demonstrated by visual fields, and verified in study participation)
  • * Willing, able, and competent to provide informed consent
  • * Cognitively able to understand and respond to written and oral instructions in English
Exclusion Criteria
  • * Past or present ocular disease interfering with visual acuity
  • * Corrected vision worse than 20/40 in either eye
  • * Presence of damage to the dorsal Lateral Geniculate Nucleus
  • * Diffuse, whole brain degenerative processes
  • * Brain damage deemed by study staff to potentially interfere with testing ability or outcome measures
  • * Documented history of traumatic brain injury
  • * Documented history of drug/alcohol abuse
  • * Current use neuroactive
  • * Cognitive or seizure disorders
  • * Subjects with one-sided attentional neglect

Understanding Visual Processing After Occipital Stroke

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