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NCT06328127 | NOT YET RECRUITING | Hematopoietic Stem Cell Transplant

Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors
Sponsor:

Brigham and Women's Hospital

Information provided by (Responsible Party):

Hermioni L.Amonoo, MD, MPP, MPH

Brief Summary:

This randomized clinical trial is evaluating the impact of a positive psychology intervention (PATH) on anxiety symptoms, depression symptoms, and quality of life in survivors of hematopoietic stem cell transplant (HSCT) compared to usual care.

Condition or disease

Hematopoietic Stem Cell Transplant

Intervention/treatment

PATH

Phase

NA

Detailed Description:

Patients undergoing hematopoietic stem cell transplantation (HSCT) deal with numerous physical and psychological symptoms during acute hospitalization and recovery. Of the few psychosocial interventions tailored to the needs of the HSCT population, most focus on the needs of patients in the pre-transplant phase or during the HSCT hospitalization, but not during the acute recovery period starting at 100-days post-HSCT. Hence, the investigators developed a remotely-delivered positive psychology intervention, Positive Affect in the Transplantation of Hematopoietic Stem Cells (PATH). This intervention encourages patients to perform simple and enjoyable structured activities that increase the intensity of positive thoughts and emotions. With this multi-site randomized clinical trial, the investigators aim to find out whether PATH can improve psychological distress and quality of life in HSCT survivors, compared to usual care, using validated assessment tools.

Study Type : INTERVENTIONAL
Estimated Enrollment : 400 participants
Masking : NONE
Primary Purpose : SUPPORTIVE_CARE
Official Title : Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors
Actual Study Start Date : 2024-12-31
Estimated Primary Completion Date : 2028-06-30
Estimated Study Completion Date : 2030-04-30

Information not available for Arms and Intervention/treatment

Ages Eligible for Study: 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Criteria
Inclusion Criteria
  • * Adult patients (aged 18 years and older) undergoing allogeneic HSCT and are approaching 100-days post-HSCT
  • * Ability to speak, read, and respond to questions in English or Spanish to complete study procedures
  • * Access to a basic telephone
Exclusion Criteria
  • * Patients who underwent allogeneic HSCT for benign hematologic conditions
  • * Patients who received outpatient HSCT
  • * Patients with severe psychiatric or cognitive conditions, such as dementia, determined by their transplant oncologist to make them unable to provide informed consent or comply with study procedures
Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors

Location Details

NCT06328127

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How to Participate

Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.

Locations

Not yet recruiting

United States, Florida

Moffitt Cancer Center

Tampa, florida, United States, 33612

Not yet recruiting

United States, Massachusetts

Dana Farber Cancer Institute

Boston, Massachusetts, United States, 02215

Not yet recruiting

United States, North Carolina

Duke Cancer Institute

Durham, North Carolina, United States, 27710