University of Tartu
Kaspar Tootsi
Total joint arthroplasty is one of the best treatment options for end-stage osteoarthritis. Cemented hip arthroplasty is mainly indicated for elderly patients with poor bone quality and multiple comorbidities. Bone cement implantation syndrome is associated with cemented hip arthroplasty and it has been shown to increase cardiovascular and renal complication and brain damage postoperatively. The aim of this project is to elucidate whether remote-ischemic preconditioning (RIPC) has multi-organ protective effect in cemented hip arthroplasty patients.
Osteoarthritis, Hip
Cardiovascular Diseases
Bone Cement Implantation Syndrome
Kidney Diseases
Remote Ischemic Preconditioning
SHAM
NA
Total joint arthroplasty is one of the best treatment options for end-stage osteoarthritis. Cemented hip arthroplasty is mainly indicated for elderly patients with poor bone quality and multiple comorbidities. Cemented hip arthroplasty is strongly associated with bone cement implantation syndrome (BCIS). It is characterized by hypoxia, hypotension and/or unexpected loss of consciousness occurring around the time of cementation, prosthesis insertion or reduction of the joint. It has been shown to increase cardiovascular and renal complication and brain damage postoperatively. Remote-ischemic preconditioning has shown kidney, myocardial and brain injury protective effect on non-cardiac surgery patients. The aim of this project is to elucidate whether remote-ischemic preconditioning (RIPC) has multi-organ protective effect in cemented hip arthroplasty patients.
| Study Type : | INTERVENTIONAL |
| Estimated Enrollment : | 200 participants |
| Masking : | QUADRUPLE |
| Masking Description : | Randomization and intervention is done by a dedicated study nurse. Patient, orthopedic surgeon, investigator and outcomes assessor and statistician are all blinded to the study intervention. |
| Primary Purpose : | PREVENTION |
| Official Title : | Effects of Remote Ischaemic Preconditioning in Cemented Total Hip Arthroplasty: Randomized Controlled Trial |
| Actual Study Start Date : | 2024-03-20 |
| Estimated Primary Completion Date : | 2026-03 |
| Estimated Study Completion Date : | 2027-03 |
Information not available for Arms and Intervention/treatment
| Ages Eligible for Study: | 65 Years to 90 Years |
| Sexes Eligible for Study: | ALL |
| Accepts Healthy Volunteers: |
Want to participate in this study, select a site at your convenience, send yourself email to get contact details and prescreening steps.
RECRUITING
University of Tartu
Tartu, Tartu, Estonia, 50406